tetano
Editor, Senior Moderator
Immunol Res
. 2023 Jun 14.
doi: 10.1007/s12026-023-09371-7. Online ahead of print. COVID-19 infection: a possible induction factor for development of autoimmune diseases?
Nikoo Saeedi[SUP] #[/SUP][SUP] 1 [/SUP], Narjes Sadat Farizani Gohari[SUP] #[/SUP][SUP] 2 3 [/SUP], Amir Ali Moodi Ghalibaf[SUP] 4 5 [/SUP], Ali Dehghan[SUP] 6 [/SUP], Mohammad Bagher Owlia[SUP] 6 [/SUP]
Affiliations
Following the global spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the importance of investigation of the pathogenesis and immunological characteristics of COVID-19 became quite clear. Currently, there are reports indicating that COVID-19 is able to induce autoimmune responses. Abnormal immune reactions are a cornerstone in the pathogenicity of both conditions. Detection of autoantibodies in COVID-19 patients may suggest a link between COVID-19 and autoimmunity. In this study, we focused on the similarities and possible differences between COVID-19 and autoimmune disorders to explore the relationship between them. Comparing the pathogenicity of SARS-CoV-2 infection with autoimmune conditions revealed significant immunological properties of COVID-19 including the presence of several autoantibodies, autoimmunity-related cytokines, and cellular activities that could be useful in future clinical studies aiming at managing this pandemic.
Keywords: Autoimmune diseases; COVID-19; Cytokines; Pathogenesis.
. 2023 Jun 14.
doi: 10.1007/s12026-023-09371-7. Online ahead of print. COVID-19 infection: a possible induction factor for development of autoimmune diseases?
Nikoo Saeedi[SUP] #[/SUP][SUP] 1 [/SUP], Narjes Sadat Farizani Gohari[SUP] #[/SUP][SUP] 2 3 [/SUP], Amir Ali Moodi Ghalibaf[SUP] 4 5 [/SUP], Ali Dehghan[SUP] 6 [/SUP], Mohammad Bagher Owlia[SUP] 6 [/SUP]
Affiliations
- PMID: 37316687
- DOI: 10.1007/s12026-023-09371-7
Following the global spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the importance of investigation of the pathogenesis and immunological characteristics of COVID-19 became quite clear. Currently, there are reports indicating that COVID-19 is able to induce autoimmune responses. Abnormal immune reactions are a cornerstone in the pathogenicity of both conditions. Detection of autoantibodies in COVID-19 patients may suggest a link between COVID-19 and autoimmunity. In this study, we focused on the similarities and possible differences between COVID-19 and autoimmune disorders to explore the relationship between them. Comparing the pathogenicity of SARS-CoV-2 infection with autoimmune conditions revealed significant immunological properties of COVID-19 including the presence of several autoantibodies, autoimmunity-related cytokines, and cellular activities that could be useful in future clinical studies aiming at managing this pandemic.
Keywords: Autoimmune diseases; COVID-19; Cytokines; Pathogenesis.