tetano
Editor, Senior Moderator
Diagn Microbiol Infect Dis. 2018 Nov 24. pii: S0732-8893(18)30664-3. doi: 10.1016/j.diagmicrobio.2018.11.014. [Epub ahead of print]
[h=1]Impact of bacterial and viral coinfection in community-acquired pneumonia in adults.[/h] Lim YK[SUP]1[/SUP], Kweon OJ[SUP]2[/SUP], Kim HR[SUP]3[/SUP], Kim TH[SUP]4[/SUP], Lee MK[SUP]5[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Bacterial and viral coinfected community-acquired pneumonia (CAP) is poorly characterized in adults. The aim of this study was to investigate the influence of bacterial and viral coinfection in patients with CAP. A total of 235 adults who requested molecular tests of pneumonia and were diagnosed with CAP were enrolled in this study. Microbiological tests included blood and sputum cultures, PCR for bacterial and viral pathogens, antigen test for Streptococcus pneumoniae and the influenza virus, and antibody detection of Mycoplasma pneumonia. Of the 235 patients, 32 (13.6%) patients were coinfected with bacteria and virus. Among 64 severe CAP patients, the concurrent infections were confirmed in 14 patients (21.9%). The proportion of severe pneumonia was significantly higher in patients with coinfection, and they showed a significantly higher mortality rate. In conclusion, bacterial and viral coinfection in CAP is not a rare occurrence in adults. Viral and bacterial coinfections have an adverse impact on the severity of the pneumonia, and increase morbidity and mortality in patients with CAP.
[h=4]KEYWORDS:[/h] Bacteria; Coinfection; Community-acquired pneumonia; Mortality; Severe pneumonia; Virus
PMID: 30578007 DOI: 10.1016/j.diagmicrobio.2018.11.014
[h=1]Impact of bacterial and viral coinfection in community-acquired pneumonia in adults.[/h] Lim YK[SUP]1[/SUP], Kweon OJ[SUP]2[/SUP], Kim HR[SUP]3[/SUP], Kim TH[SUP]4[/SUP], Lee MK[SUP]5[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Bacterial and viral coinfected community-acquired pneumonia (CAP) is poorly characterized in adults. The aim of this study was to investigate the influence of bacterial and viral coinfection in patients with CAP. A total of 235 adults who requested molecular tests of pneumonia and were diagnosed with CAP were enrolled in this study. Microbiological tests included blood and sputum cultures, PCR for bacterial and viral pathogens, antigen test for Streptococcus pneumoniae and the influenza virus, and antibody detection of Mycoplasma pneumonia. Of the 235 patients, 32 (13.6%) patients were coinfected with bacteria and virus. Among 64 severe CAP patients, the concurrent infections were confirmed in 14 patients (21.9%). The proportion of severe pneumonia was significantly higher in patients with coinfection, and they showed a significantly higher mortality rate. In conclusion, bacterial and viral coinfection in CAP is not a rare occurrence in adults. Viral and bacterial coinfections have an adverse impact on the severity of the pneumonia, and increase morbidity and mortality in patients with CAP.
[h=4]KEYWORDS:[/h] Bacteria; Coinfection; Community-acquired pneumonia; Mortality; Severe pneumonia; Virus
PMID: 30578007 DOI: 10.1016/j.diagmicrobio.2018.11.014