tetano
Editor, Senior Moderator
Influenza Other Respir Viruses. 2019 Jan 30. doi: 10.1111/irv.12633. [Epub ahead of print]
[h=1]Impact of influenza on hospitalization rates in children with a range of chronic lung diseases.[/h] Homaira N[SUP]1,[/SUP][SUP]2[/SUP], Briggs N[SUP]3[/SUP], Oei JL[SUP]1,[/SUP][SUP]4[/SUP], Hilder L[SUP]1,[/SUP][SUP]5[/SUP], Bajuk B[SUP]6[/SUP], Snelling T[SUP]7,[/SUP][SUP]8,[/SUP][SUP]9,[/SUP][SUP]10[/SUP], Chambers GM[SUP]1,[/SUP][SUP]5,[/SUP][SUP]11[/SUP], Jaffe A[SUP]1,[/SUP][SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Data on burden of severe influenza in children with a range of chronic lung diseases (CLDs) remain limited.
[h=4]METHOD:[/h] We performed a cohort study to estimate burden of influenza-associated hospitalization in children with CLDs using population-based linked data. The cohort comprised all children in New South Wales, Australia, born between 2001 and 2010 and was divided into five groups, children with: (a) severe asthma; (b) bronchopulmonary dysplasia (BPD); (c) cystic fibrosis (CF); (d) other congenital/chronic lung conditions; and (e) children without CLDs. Incidence rates and rate ratios for influenza-associated hospitalization were calculated for 2001-2011. Average cost/episode of hospitalization was estimated using public hospital cost weights.
[h=4]RESULTS:[/h] Our cohort comprised 888 157 children; 11 058 (1.2%) had one of the CLDs. The adjusted incidence/1000 child-years of influenza-associated hospitalization in children with CLDs was 3.9 (95% CI: 2.6-5.2) and 0.7 (95% CI: 0.5-0.9) for children without. The rate ratio was 5.4 in children with CLDs compared to children without. The adjusted incidence/1000 child-years (95% CI) in children with severe asthma was 1.1 (0.6-1.6), with BPD was 6.0 (3.7-8.3), with CF was 7.4 (2.6-12.1), and with other congenital/chronic lung conditions was 6.9 (4.9-8.9). The cost/episode (95% CI) of influenza-associated hospitalization was AUD 19 704 (95% CI: 11 715-27 693) for children with CLDs compared to 4557 (95% CI: 4129-4984) for children without.
[h=4]DISCUSSION:[/h] This large population-based study suggests a significant healthcare burden associated with influenza in children with a range of CLDs.
? 2019 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd.
[h=4]KEYWORDS:[/h] chronic lung diseases; influenza burden; pediatrics
PMID: 30701672 DOI: 10.1111/irv.12633
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[h=1]Impact of influenza on hospitalization rates in children with a range of chronic lung diseases.[/h] Homaira N[SUP]1,[/SUP][SUP]2[/SUP], Briggs N[SUP]3[/SUP], Oei JL[SUP]1,[/SUP][SUP]4[/SUP], Hilder L[SUP]1,[/SUP][SUP]5[/SUP], Bajuk B[SUP]6[/SUP], Snelling T[SUP]7,[/SUP][SUP]8,[/SUP][SUP]9,[/SUP][SUP]10[/SUP], Chambers GM[SUP]1,[/SUP][SUP]5,[/SUP][SUP]11[/SUP], Jaffe A[SUP]1,[/SUP][SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Data on burden of severe influenza in children with a range of chronic lung diseases (CLDs) remain limited.
[h=4]METHOD:[/h] We performed a cohort study to estimate burden of influenza-associated hospitalization in children with CLDs using population-based linked data. The cohort comprised all children in New South Wales, Australia, born between 2001 and 2010 and was divided into five groups, children with: (a) severe asthma; (b) bronchopulmonary dysplasia (BPD); (c) cystic fibrosis (CF); (d) other congenital/chronic lung conditions; and (e) children without CLDs. Incidence rates and rate ratios for influenza-associated hospitalization were calculated for 2001-2011. Average cost/episode of hospitalization was estimated using public hospital cost weights.
[h=4]RESULTS:[/h] Our cohort comprised 888 157 children; 11 058 (1.2%) had one of the CLDs. The adjusted incidence/1000 child-years of influenza-associated hospitalization in children with CLDs was 3.9 (95% CI: 2.6-5.2) and 0.7 (95% CI: 0.5-0.9) for children without. The rate ratio was 5.4 in children with CLDs compared to children without. The adjusted incidence/1000 child-years (95% CI) in children with severe asthma was 1.1 (0.6-1.6), with BPD was 6.0 (3.7-8.3), with CF was 7.4 (2.6-12.1), and with other congenital/chronic lung conditions was 6.9 (4.9-8.9). The cost/episode (95% CI) of influenza-associated hospitalization was AUD 19 704 (95% CI: 11 715-27 693) for children with CLDs compared to 4557 (95% CI: 4129-4984) for children without.
[h=4]DISCUSSION:[/h] This large population-based study suggests a significant healthcare burden associated with influenza in children with a range of CLDs.
? 2019 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd.
[h=4]KEYWORDS:[/h] chronic lung diseases; influenza burden; pediatrics
PMID: 30701672 DOI: 10.1111/irv.12633
Free full text