tetano
Editor, Senior Moderator
J Theor Biol. 2020 Feb 6:110190. doi: 10.1016/j.jtbi.2020.110190. [Epub ahead of print] [h=1]Impact of influenza vaccine-modified infectivity on attack rate, case fatality ratio and mortality.[/h]
Nah K[SUP]1[/SUP], Alavinejad M[SUP]1[/SUP], Rahman A[SUP]2[/SUP], Heffernan JM[SUP]3[/SUP], Wu J[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Generally, vaccines are designed to provide protection against infection (susceptibility), disease (symptoms and transmissibility), and/or complications. In a recent study of influenza vaccination, it was observed that vaccinated yet infected individuals experienced increased transmission levels. In this paper, using a mathematical model of infection and transmission, we study the impact of vaccine-modified effects, including susceptibility and infectivity, on important epidemiological outcomes of an immunization program. The balance between vaccine-modified susceptibility, infectivity and recovery needed in preventing an influenza outbreak, or in mitigating the health outcomes of the outbreak is studied using the SIRV-type of disease transmission model. We also investigate the impact of influenza vaccination program on the infection risk of vaccinated and non-vaccinated individuals.
Copyright ? 2020. Published by Elsevier Ltd.
[h=4]KEYWORDS:[/h] Attack rate; Attack ratio; Influenza virus; Mathematical modelling; Vaccination impact
PMID: 32035827 DOI: 10.1016/j.jtbi.2020.110190
Nah K[SUP]1[/SUP], Alavinejad M[SUP]1[/SUP], Rahman A[SUP]2[/SUP], Heffernan JM[SUP]3[/SUP], Wu J[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Generally, vaccines are designed to provide protection against infection (susceptibility), disease (symptoms and transmissibility), and/or complications. In a recent study of influenza vaccination, it was observed that vaccinated yet infected individuals experienced increased transmission levels. In this paper, using a mathematical model of infection and transmission, we study the impact of vaccine-modified effects, including susceptibility and infectivity, on important epidemiological outcomes of an immunization program. The balance between vaccine-modified susceptibility, infectivity and recovery needed in preventing an influenza outbreak, or in mitigating the health outcomes of the outbreak is studied using the SIRV-type of disease transmission model. We also investigate the impact of influenza vaccination program on the infection risk of vaccinated and non-vaccinated individuals.
Copyright ? 2020. Published by Elsevier Ltd.
[h=4]KEYWORDS:[/h] Attack rate; Attack ratio; Influenza virus; Mathematical modelling; Vaccination impact
PMID: 32035827 DOI: 10.1016/j.jtbi.2020.110190