tetano
Editor, Senior Moderator
Int J Gynaecol Obstet. 2017 Oct 6. doi: 10.1002/ijgo.12341. [Epub ahead of print]
[h=1]Impact of maternal vaccination timing and influenza virus circulation on birth outcomes in rural Nepal.[/h] Kozuki N[SUP]1[/SUP], Katz J[SUP]1[/SUP], Englund JA[SUP]2[/SUP], Steinhoff MC[SUP]3[/SUP], Khatry SK[SUP]4[/SUP], Shrestha L[SUP]5[/SUP], Kuypers J[SUP]6[/SUP], Mullany LC[SUP]1[/SUP], Chu HY[SUP]7[/SUP], LeClerq SC[SUP]1,[/SUP][SUP]4[/SUP], Tielsch JM[SUP]8[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]OBJECTIVE:[/h] To describe the effect of maternal vaccination on birth outcomes in rural Nepal, modified by timing of vaccination in pregnancy and influenza virus activity.
[h=4]METHODS:[/h] A secondary analysis was conducted using data from two annual cohorts of a randomized controlled trial. A total of 3693 pregnant women from Sarlahi District were enrolled between April 25, 2011, and September 9, 2013. All participants were aged 15-40 years and received a trivalent inactivated influenza vaccine or placebo. The outcome measures included birth weight, pregnancy length, low birth weight (<2500 g), preterm birth, and small-for-gestational-age birth.
[h=4]RESULTS:[/h] Data were available on birth weight for 2741 births and on pregnancy length for 3623 births. Maternal vaccination increased mean birthweight by 42 g (95% confidence interval [CI] 8-76). The magnitude of this increase varied by season but was greatest among pregnancies with high influenza virus circulation during the third trimester. Birth weight increased by 111 g (95% CI -51 to 273) when 75%-100% of a pregnancy's third trimester had high influenza virus circulation versus 38 g (95% CI -6 to 81) when 0%-25% of a pregnancy's third trimester had high influenza virus circulation. However, these results were nonsignificant.
[h=4]CONCLUSION:[/h] Seasonal maternal influenza vaccination in rural Nepal increased birth weight; the magnitude appeared larger during periods of high influenza virus circulation. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
[h=4]KEYWORDS:[/h] Influenza; Low birth weight; Nepal; Pregnancy; Preterm; Small for gestational age; Vaccination
PMID: 28984909 DOI: 10.1002/ijgo.12341
[h=1]Impact of maternal vaccination timing and influenza virus circulation on birth outcomes in rural Nepal.[/h] Kozuki N[SUP]1[/SUP], Katz J[SUP]1[/SUP], Englund JA[SUP]2[/SUP], Steinhoff MC[SUP]3[/SUP], Khatry SK[SUP]4[/SUP], Shrestha L[SUP]5[/SUP], Kuypers J[SUP]6[/SUP], Mullany LC[SUP]1[/SUP], Chu HY[SUP]7[/SUP], LeClerq SC[SUP]1,[/SUP][SUP]4[/SUP], Tielsch JM[SUP]8[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]OBJECTIVE:[/h] To describe the effect of maternal vaccination on birth outcomes in rural Nepal, modified by timing of vaccination in pregnancy and influenza virus activity.
[h=4]METHODS:[/h] A secondary analysis was conducted using data from two annual cohorts of a randomized controlled trial. A total of 3693 pregnant women from Sarlahi District were enrolled between April 25, 2011, and September 9, 2013. All participants were aged 15-40 years and received a trivalent inactivated influenza vaccine or placebo. The outcome measures included birth weight, pregnancy length, low birth weight (<2500 g), preterm birth, and small-for-gestational-age birth.
[h=4]RESULTS:[/h] Data were available on birth weight for 2741 births and on pregnancy length for 3623 births. Maternal vaccination increased mean birthweight by 42 g (95% confidence interval [CI] 8-76). The magnitude of this increase varied by season but was greatest among pregnancies with high influenza virus circulation during the third trimester. Birth weight increased by 111 g (95% CI -51 to 273) when 75%-100% of a pregnancy's third trimester had high influenza virus circulation versus 38 g (95% CI -6 to 81) when 0%-25% of a pregnancy's third trimester had high influenza virus circulation. However, these results were nonsignificant.
[h=4]CONCLUSION:[/h] Seasonal maternal influenza vaccination in rural Nepal increased birth weight; the magnitude appeared larger during periods of high influenza virus circulation. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
[h=4]KEYWORDS:[/h] Influenza; Low birth weight; Nepal; Pregnancy; Preterm; Small for gestational age; Vaccination
PMID: 28984909 DOI: 10.1002/ijgo.12341