tetano
Editor, Senior Moderator
BMC Public Health. 2019 Dec 16;19(1):1690. doi: 10.1186/s12889-019-7958-8. [h=1]Impact of national influenza vaccination strategy in severe influenza outcomes among the high-risk Portuguese population.[/h]
Machado A[SUP]1,[/SUP][SUP]2[/SUP], Kislaya I[SUP]3,[/SUP][SUP]4[/SUP], Larrauri A[SUP]5[/SUP], Matias Dias C[SUP]3,[/SUP][SUP]4[/SUP], Nunes B[SUP]3,[/SUP][SUP]4[/SUP].
[h=3]Author information[/h] 1 Departamento de Epidemiologia, Instituto Nacional de Sa?de Doutor Ricardo Jorge, Av. Padre Cruz, 1649-016, Lisbon, Portugal. ausenda.machado@insa.min-saude.pt. 2 NOVA National School of Public Health, Public Health Research Centre, Universidade NOVA de Lisboa, Lisbon, Portugal. ausenda.machado@insa.min-saude.pt. 3 Departamento de Epidemiologia, Instituto Nacional de Sa?de Doutor Ricardo Jorge, Av. Padre Cruz, 1649-016, Lisbon, Portugal. 4 NOVA National School of Public Health, Public Health Research Centre, Universidade NOVA de Lisboa, Lisbon, Portugal. 5 National Centre of Epidemiology, Institute of Health Carlos III CIBER de Epidemiolog?a y Salud P?blica (CIBERESP), Madrid, Spain.
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] All aged individuals with a chronic condition and those with 65 and more years are at increased risk of severe influenza post-infection complications. There is limited research on cases averted by the yearly vaccination programs in high-risk individuals. The objective was to estimate the impact of trivalent seasonal influenza vaccination on averted hospitalizations and death among the high-risk population in Portugal.
[h=4]METHODS:[/h] The impact of trivalent seasonal influenza vaccination was estimated using vaccine coverage, vaccine effectiveness and the number of influenza-related hospitalizations and deaths. The number of averted events (NAE), prevented fraction (PF) and number needed to vaccinate (NVN) were estimated for seasons 2014/15 to 2016/17.
[h=4]RESULTS:[/h] The vaccination strategy averted on average approximately 1833 hospitalizations and 383 deaths per season. Highest NAE was observed in the ≥65 years population (85% of hospitalizations and 95% deaths) and in the 2016/17 season (1957 hospitalizations and 439 deaths). On average, seasonal vaccination prevented 21% of hospitalizations in the population aged 65 and more, and 18.5% in the population with chronic conditions. The vaccination also prevented 29% and 19.5% of deaths in each group of the high-risk population. It would be needed to vaccinate 3360 high-risk individuals, to prevent one hospitalization and 60,471 high-risk individuals to prevent one death.
[h=4]CONCLUSION:[/h] The yearly influenza vaccination campaigns had a sustained positive benefit for the high-risk population, reducing hospitalizations and deaths. These results can support public health plans toward increased vaccine coverage in high-risk groups.
PMID: 31842831 DOI: 10.1186/s12889-019-7958-8
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Machado A[SUP]1,[/SUP][SUP]2[/SUP], Kislaya I[SUP]3,[/SUP][SUP]4[/SUP], Larrauri A[SUP]5[/SUP], Matias Dias C[SUP]3,[/SUP][SUP]4[/SUP], Nunes B[SUP]3,[/SUP][SUP]4[/SUP].
[h=3]Author information[/h] 1 Departamento de Epidemiologia, Instituto Nacional de Sa?de Doutor Ricardo Jorge, Av. Padre Cruz, 1649-016, Lisbon, Portugal. ausenda.machado@insa.min-saude.pt. 2 NOVA National School of Public Health, Public Health Research Centre, Universidade NOVA de Lisboa, Lisbon, Portugal. ausenda.machado@insa.min-saude.pt. 3 Departamento de Epidemiologia, Instituto Nacional de Sa?de Doutor Ricardo Jorge, Av. Padre Cruz, 1649-016, Lisbon, Portugal. 4 NOVA National School of Public Health, Public Health Research Centre, Universidade NOVA de Lisboa, Lisbon, Portugal. 5 National Centre of Epidemiology, Institute of Health Carlos III CIBER de Epidemiolog?a y Salud P?blica (CIBERESP), Madrid, Spain.
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] All aged individuals with a chronic condition and those with 65 and more years are at increased risk of severe influenza post-infection complications. There is limited research on cases averted by the yearly vaccination programs in high-risk individuals. The objective was to estimate the impact of trivalent seasonal influenza vaccination on averted hospitalizations and death among the high-risk population in Portugal.
[h=4]METHODS:[/h] The impact of trivalent seasonal influenza vaccination was estimated using vaccine coverage, vaccine effectiveness and the number of influenza-related hospitalizations and deaths. The number of averted events (NAE), prevented fraction (PF) and number needed to vaccinate (NVN) were estimated for seasons 2014/15 to 2016/17.
[h=4]RESULTS:[/h] The vaccination strategy averted on average approximately 1833 hospitalizations and 383 deaths per season. Highest NAE was observed in the ≥65 years population (85% of hospitalizations and 95% deaths) and in the 2016/17 season (1957 hospitalizations and 439 deaths). On average, seasonal vaccination prevented 21% of hospitalizations in the population aged 65 and more, and 18.5% in the population with chronic conditions. The vaccination also prevented 29% and 19.5% of deaths in each group of the high-risk population. It would be needed to vaccinate 3360 high-risk individuals, to prevent one hospitalization and 60,471 high-risk individuals to prevent one death.
[h=4]CONCLUSION:[/h] The yearly influenza vaccination campaigns had a sustained positive benefit for the high-risk population, reducing hospitalizations and deaths. These results can support public health plans toward increased vaccine coverage in high-risk groups.
PMID: 31842831 DOI: 10.1186/s12889-019-7958-8
Free full text