tetano
Editor, Senior Moderator
Vaccine. 2010 Sep 11. [Epub ahead of print]
Impact of prior seasonal influenza vaccination and infection on pandemic A(H1N1) influenza virus replication in ferrets.
Ellebedy AH, Ducatez MF, Duan S, Stigger-Rosser E, Rubrum AM, Govorkova EA, Webster RG, Webby RJ.
Department of Infectious Diseases, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105-3678, USA.
Abstract
Early epidemiologic and serologic studies have suggested preexisting immunity to the pandemic A(H1N1) 2009 influenza virus (H1N1pdm) may be altering its morbidity and mortality in humans. To determine the role that contemporary seasonal H1N1 virus infection or trivalent inactivated vaccine (TIV) might be playing in this immunity we conducted a vaccination-challenge study in ferrets. Vaccination with TIV was unable to alter subsequent morbidity or contact transmission in ferrets following challenge with H1N1pdm. Conversely, prior infection with the contemporary seasonal H1N1 strain altered morbidity, but not transmission, of H1N1pdm despite the detection of only minimal levels of cross-reactive antibodies.
PMID: 20840835 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/20840835
Impact of prior seasonal influenza vaccination and infection on pandemic A(H1N1) influenza virus replication in ferrets.
Ellebedy AH, Ducatez MF, Duan S, Stigger-Rosser E, Rubrum AM, Govorkova EA, Webster RG, Webby RJ.
Department of Infectious Diseases, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105-3678, USA.
Abstract
Early epidemiologic and serologic studies have suggested preexisting immunity to the pandemic A(H1N1) 2009 influenza virus (H1N1pdm) may be altering its morbidity and mortality in humans. To determine the role that contemporary seasonal H1N1 virus infection or trivalent inactivated vaccine (TIV) might be playing in this immunity we conducted a vaccination-challenge study in ferrets. Vaccination with TIV was unable to alter subsequent morbidity or contact transmission in ferrets following challenge with H1N1pdm. Conversely, prior infection with the contemporary seasonal H1N1 strain altered morbidity, but not transmission, of H1N1pdm despite the detection of only minimal levels of cross-reactive antibodies.
PMID: 20840835 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/20840835