tetano
Editor, Senior Moderator
J Med Virol. 2015 May 27. doi: 10.1002/jmv.24279. [Epub ahead of print]
[h=1]Impact of rapid influenza PCR testing on hospitalization and antiviral use: A retrospective cohort study.[/h] Chu HY[SUP]1[/SUP], Englund JA[SUP]2[/SUP], Huang D[SUP]1[/SUP], Scott E[SUP]1[/SUP], Chan JD[SUP]3[/SUP], Jain R[SUP]3[/SUP], Pottinger PS[SUP]1[/SUP], Lynch JB[SUP]1[/SUP], Dellit TH[SUP]1[/SUP], Jerome KR[SUP]4[/SUP], Kuypers J[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Rapid PCR-based influenza tests are increasingly used as point-of-care diagnostics in hospitals and clinics. To our knowledge, no prior studies have described clinical outcomes with implementation of rapid PCR-based influenza tests in hospitalized adult inpatients. Electronic medical records were used to assess differences in laboratory testing time and antiviral use among a subset of 175 consecutive adult inpatients tested for influenza in two respiratory seasons before and after implementation of rapid PCR-based influenza testing at an academic medical center. Of the 350 hospitalized inpatients included in this analysis, 96 (27%) were over 65 years of age and 308 (88%) had a comorbid condition. The overall time to result decreased significantly from 25.2 to 1.7 hours (P < 0.001) after implementation of rapid PCR-based influenza testing. Among influenza-negative patients, the frequency of oseltamivir initiation remained unchanged (before: 43% vs. after: 45%; P = 0.60), though the median duration of oseltamivir was significantly decreased from 1.1 to 0.0 days (P < 0.001). By providing an earlier result to clinicians, rapid PCR-based influenza tests may decrease unnecessary antiviral use among adult inpatients who test negative for influenza. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
[h=4]KEYWORDS:[/h] Influenza; PCR; infection control; oseltamivir
PMID: 26017150 [PubMed - as supplied by publisher]
[h=1]Impact of rapid influenza PCR testing on hospitalization and antiviral use: A retrospective cohort study.[/h] Chu HY[SUP]1[/SUP], Englund JA[SUP]2[/SUP], Huang D[SUP]1[/SUP], Scott E[SUP]1[/SUP], Chan JD[SUP]3[/SUP], Jain R[SUP]3[/SUP], Pottinger PS[SUP]1[/SUP], Lynch JB[SUP]1[/SUP], Dellit TH[SUP]1[/SUP], Jerome KR[SUP]4[/SUP], Kuypers J[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Rapid PCR-based influenza tests are increasingly used as point-of-care diagnostics in hospitals and clinics. To our knowledge, no prior studies have described clinical outcomes with implementation of rapid PCR-based influenza tests in hospitalized adult inpatients. Electronic medical records were used to assess differences in laboratory testing time and antiviral use among a subset of 175 consecutive adult inpatients tested for influenza in two respiratory seasons before and after implementation of rapid PCR-based influenza testing at an academic medical center. Of the 350 hospitalized inpatients included in this analysis, 96 (27%) were over 65 years of age and 308 (88%) had a comorbid condition. The overall time to result decreased significantly from 25.2 to 1.7 hours (P < 0.001) after implementation of rapid PCR-based influenza testing. Among influenza-negative patients, the frequency of oseltamivir initiation remained unchanged (before: 43% vs. after: 45%; P = 0.60), though the median duration of oseltamivir was significantly decreased from 1.1 to 0.0 days (P < 0.001). By providing an earlier result to clinicians, rapid PCR-based influenza tests may decrease unnecessary antiviral use among adult inpatients who test negative for influenza. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
[h=4]KEYWORDS:[/h] Influenza; PCR; infection control; oseltamivir
PMID: 26017150 [PubMed - as supplied by publisher]