tetano
Editor, Senior Moderator
J Cyst Fibros. 2011 Jul 11. [Epub ahead of print]
Impact of the A (H1N1) pandemic influenza (season 2009-2010) on patients with cystic fibrosis.
Viviani L, Assael BM, Kerem E; The ECFS (A) H1N1 study group.
Source
Dipartimento di Medicina del Lavoro "Clinica del Lavoro L. Devoto", Sezione di Statistica Medica e Biometria "G.A.Maccacaro", Universit? degli Studi di Milano, Italy.
Abstract
BACKGROUND:
Influenza, like other respiratory viral infections, can cause acute deterioration of lung function in patients with cystic fibrosis (CF). Previous studies on a small number of patients reported that most people with CF infected with A (H1N1) influenza experienced a mild course of disease.
AIM:
To characterise the impact of A (H1N1) infection on CF in a large number of patients from different centres and countries.
METHODS:
CF centres accessing the web-site of the European Cystic Fibrosis Society (ECFS) were asked to report clinical data on patients with an ascertained diagnosis of influenza caused by the A (H1N1) virus. The study was web-based and data were collected through an electronic data sheet on the ECFS website.
RESULTS:
Twenty-five centres from 10 countries caring for 4698 patients with CF reported data on 110 patients (2.3%), median age 13years (range 1-39years). The prevalence of infection in each centre ranged from 0% to 9.4%. Only 8.8% of the patients had been vaccinated. The main symptoms were fever and respiratory exacerbation requiring IV antibiotics in 53% of the patients; 48% of the patients were hospitalised for an average of 12.9days (range 2-56) and 31% required oxygen treatment during the time of the infection. Most of the patients recovered and FEV(1) 1month after the infection was similar to that before the infection. However, 6 patients were admitted to ICU, 5 with mechanical ventilation. Three patients with severe respiratory disease died.
CONCLUSIONS:
A (H1N1) influenza infection caused transient but significant morbidity in most of the patients with CF. However, in a small number of patients with severe lung disease, A (H1N1) influenza was associated with respiratory deterioration, mechanical ventilation and even death.
Copyright ? 2011 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.
PMID:
21752728
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/21752728
Impact of the A (H1N1) pandemic influenza (season 2009-2010) on patients with cystic fibrosis.
Viviani L, Assael BM, Kerem E; The ECFS (A) H1N1 study group.
Source
Dipartimento di Medicina del Lavoro "Clinica del Lavoro L. Devoto", Sezione di Statistica Medica e Biometria "G.A.Maccacaro", Universit? degli Studi di Milano, Italy.
Abstract
BACKGROUND:
Influenza, like other respiratory viral infections, can cause acute deterioration of lung function in patients with cystic fibrosis (CF). Previous studies on a small number of patients reported that most people with CF infected with A (H1N1) influenza experienced a mild course of disease.
AIM:
To characterise the impact of A (H1N1) infection on CF in a large number of patients from different centres and countries.
METHODS:
CF centres accessing the web-site of the European Cystic Fibrosis Society (ECFS) were asked to report clinical data on patients with an ascertained diagnosis of influenza caused by the A (H1N1) virus. The study was web-based and data were collected through an electronic data sheet on the ECFS website.
RESULTS:
Twenty-five centres from 10 countries caring for 4698 patients with CF reported data on 110 patients (2.3%), median age 13years (range 1-39years). The prevalence of infection in each centre ranged from 0% to 9.4%. Only 8.8% of the patients had been vaccinated. The main symptoms were fever and respiratory exacerbation requiring IV antibiotics in 53% of the patients; 48% of the patients were hospitalised for an average of 12.9days (range 2-56) and 31% required oxygen treatment during the time of the infection. Most of the patients recovered and FEV(1) 1month after the infection was similar to that before the infection. However, 6 patients were admitted to ICU, 5 with mechanical ventilation. Three patients with severe respiratory disease died.
CONCLUSIONS:
A (H1N1) influenza infection caused transient but significant morbidity in most of the patients with CF. However, in a small number of patients with severe lung disease, A (H1N1) influenza was associated with respiratory deterioration, mechanical ventilation and even death.
Copyright ? 2011 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.
PMID:
21752728
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/21752728