tetano
Editor, Senior Moderator
Vaccine. 2012 Jan 6. [Epub ahead of print]
Impaired production of TNF-α by dendritic cells of older adults leads to a lower CD8+ T cell response against influenza.
Liu WM, Nahar TE, Jacobi RH, Gijzen K, van Beek J, Hak E, Jonges M, Boog CJ, van der Zeijst BA, Soethout EC.
Source
Department of Vaccinology, National Institute for Public Health and the Environment, Bilthoven, The Netherlands; Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands.
Abstract
Seasonal influenza causes more morbidity and mortality in older adults than in young adults, apparently because of a decline in immune function with increasing age, known as immunosenescence. In this study, we compared the capacity of dendritic cells (DCs) from healthy older adults (≥65years) with DCs from healthy young adults (20-40years) to initiate a T cell response against influenza. DCs from older adults were impaired in the induction of influenza-specific CD8+ T cells as compared to DCs from young adults, which was demonstrated by a decreased proliferation, an impaired production of IFN-γ and a reduced expression of the degranulation marker CD107a by CD8+ T cells. Importantly, DCs from older adults produced significantly less TNF-α, showed a decreased expression of HLA class I and had a lower maturation state after influenza virus infection. Supplementing TNF-α increased the expression of HLA class I and of maturation markers and enhanced the induction of the influenza-specific CD8+ T cell response. Together, these findings indicate that the impaired influenza-specific CD8+ T cell response in older adults is associated with a reduced production of TNF-α and with a lower DC maturation. We suggest that the production of TNF-α is a determining factor in the DC-mediated CD8+ T cell response against influenza.
Copyright ? 2011. Published by Elsevier Ltd.
PMID:
22230585
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22230585
Impaired production of TNF-α by dendritic cells of older adults leads to a lower CD8+ T cell response against influenza.
Liu WM, Nahar TE, Jacobi RH, Gijzen K, van Beek J, Hak E, Jonges M, Boog CJ, van der Zeijst BA, Soethout EC.
Source
Department of Vaccinology, National Institute for Public Health and the Environment, Bilthoven, The Netherlands; Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands.
Abstract
Seasonal influenza causes more morbidity and mortality in older adults than in young adults, apparently because of a decline in immune function with increasing age, known as immunosenescence. In this study, we compared the capacity of dendritic cells (DCs) from healthy older adults (≥65years) with DCs from healthy young adults (20-40years) to initiate a T cell response against influenza. DCs from older adults were impaired in the induction of influenza-specific CD8+ T cells as compared to DCs from young adults, which was demonstrated by a decreased proliferation, an impaired production of IFN-γ and a reduced expression of the degranulation marker CD107a by CD8+ T cells. Importantly, DCs from older adults produced significantly less TNF-α, showed a decreased expression of HLA class I and had a lower maturation state after influenza virus infection. Supplementing TNF-α increased the expression of HLA class I and of maturation markers and enhanced the induction of the influenza-specific CD8+ T cell response. Together, these findings indicate that the impaired influenza-specific CD8+ T cell response in older adults is associated with a reduced production of TNF-α and with a lower DC maturation. We suggest that the production of TNF-α is a determining factor in the DC-mediated CD8+ T cell response against influenza.
Copyright ? 2011. Published by Elsevier Ltd.
PMID:
22230585
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22230585