Impaired Recovery from Influenza A/X-31(H3N2) Infection in Mice with 8-Lipoxygenase Deficiency

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Med Sci (Basel). 2019 Apr 12;7(4). pii: E60. doi: 10.3390/medsci7040060.
[h=1]Impaired Recovery from Influenza A/X-31(H3N2) Infection in Mice with 8-Lipoxygenase Deficiency.[/h] Alfardan R[SUP]1[/SUP], Guo C[SUP]2[/SUP], Toth LA[SUP]3[/SUP], Nie D[SUP]4[/SUP].
[h=3]Author information[/h]

[h=3]Abstract[/h] Lipoxygenase-derived lipid mediators can modulate inflammation and are stimulated in response to influenza infections. We report an effect of 8-lipoxygenase (ALOX8) on the recovery of mice after infection with Influenza virus X31. We compared the responses of 3- and 6-month-old mice with a deletion of ALOX8 (ALOX8[SUP]-/-[/SUP]) to influenza infections with those of age-matched littermate wild-type mice (ALOX8[SUP]+/+[/SUP]). The duration of illness was similar in 3-month-old ALOX8[SUP]-/-[/SUP] and ALOX8[SUP]+/+[/SUP] mice. However, the 6-month-old ALOX8[SUP]-/-[/SUP] mice showed a prolonged state of illness compared with ALOX8[SUP]+/+[/SUP] mice, as evidenced by reduced body temperatures, reduced locomotor activities, and delayed weight recovery. Although residual viral RNA in the lungs at day 10 post-inoculation was significantly influenced by the age of the ALOX8[SUP]-/-[/SUP] mice, there were no significant differences between ALOX8[SUP]-/-[/SUP] and ALOX8[SUP]+/+[/SUP] mice within the same age groups. The levels of cytokines interleukin 6 (IL-6) and keratinocyte chemoattractant (KC) differed significantly between 6-month-old ALOX8[SUP]-/-[/SUP] and ALOX8[SUP]+/+[/SUP] mice 10 days after viral inoculation. Our data suggest that ALOX8 deficiency in mice leads to impaired recovery from influenza infection in an age-dependent manner.


[h=4]KEYWORDS:[/h] ALOX8; X-31; inflammation; influenza A; knockout mice; lipoxygenase; resolution

PMID: 31013822 DOI: 10.3390/medsci7040060
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