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In vitro assessment of the immunological significance of a human monoclonal antibody directed to the influenza A virus nucleoprotein

tetano

tetano

Editor, Senior Moderator
Clin Vaccine Immunol. 2013 Jun 12. [Epub ahead of print]
In vitro assessment of the immunological significance of a human monoclonal antibody directed to the influenza A virus nucleoprotein.
Bodewes R, Geelhoed-Mieras MM, Wrammert J, Ahmed R, Wilson PC, Fouchier RA, Osterhaus AD, Rimmelzwaan GF.
Source

Department of Viroscience, Erasmus MC, Dr. Molewaterplein 50, Rotterdam, the Netherlands.
Abstract

Influenza A viruses cause annual epidemics and occasionally pandemics. Antibodies directed to the conserved viral nucleoprotein (NP) may play a role in immunity against various influenza A virus subtypes. Here we assessed the immunological significance of a human monoclonal antibody directed to NP in vitro. This antibody bound to virus-infected cells, but did not display virus-neutralizing activity, complement-dependent cell-cytotoxicity or opsonization of viral antigen for improved antigen presentation to CD8+ T cells by dendritic cells.

PMID:
23761662
[PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/23761662
 
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