tetano
Editor, Senior Moderator
AIDS. 2018 Sep 17. doi: 10.1097/QAD.0000000000002022. [Epub ahead of print]
[h=1]Increased influenza-specific antibody avidity in HIV-infected females compared to HIV-infected males on antiretroviral therapy.[/h] Luo Z[SUP]1[/SUP], Ogunrinde E[SUP]1[/SUP], Li M[SUP]1[/SUP], Zhang L[SUP]2[/SUP], Martin L[SUP]3[/SUP], Zhou Z[SUP]1[/SUP], Hu Z[SUP]1,[/SUP][SUP]4[/SUP], Zhang T[SUP]1,[/SUP][SUP]5[/SUP], Li Z[SUP]1,[/SUP][SUP]6[/SUP], Zhang J[SUP]1,[/SUP][SUP]7[/SUP], Su B[SUP]6[/SUP], Zhang T[SUP]6[/SUP], Wu H[SUP]6[/SUP], Ma L[SUP]8[/SUP], Liao G[SUP]8[/SUP], Eckard AR[SUP]3,[/SUP][SUP]9[/SUP], Westerink MAJ[SUP]3[/SUP], Heath S[SUP]10[/SUP], Jiang W[SUP]1,[/SUP][SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] : It is recommended that HIV-infected individuals receive annual influenza vaccination due to their high susceptibility to influenza infection, especially among females. However, there have been few studies investigating sex-related responses to influenza vaccine in antiretroviral (ART)-treated HIV-infected subjects. In this study, 26 aviremic ART-treated HIV-infected subjects and 16 healthy controls were enrolled in the current study. Blood was collected prior to vaccination (D0), on days 7-10 (D7), and on days 14-21 (D14) following administration of the 2013-2014 seasonal influenza vaccine. A series of analyses evaluated the serological and cellular responses following influenza vaccination. Female HIV-infected subjects had increased influenza-specific antibody avidity relative to male HIV-infected subjects, but similar plasma levels of influenza-specific binding antibodies and neutralizing antibodies. Increased cycling B cells and follicular helper CD4+ T (Tfh) cells were observed in female HIV-infected subjects pre- and post-vaccination compared to male HIV-infected subjects, and cycling Tfh cells were directly correlated with influenza-specific antibody avidity. Moreover, plasma testosterone levels were inversely correlated with antibody avidity index. The magnitude of microbial translocation (plasma lipopolysaccharide (LPS)) level was directly correlated with influenza-specific antibody avidity. Circulating 16S rDNA microbiome showed that enrichment of specific species within Proteobacteria was associated with influenza-specific antibody avidity. These results, including differences based on sex and correlations, were only observed in HIV+ subjects but not in the healthy controls. This study demonstrated sex differences in influenza-specific antibody avidity in ART-treated HIV disease, and provides valuable information on vaccination strategy in the ART-treated HIV-infected population.
PMID: 30234599 DOI: 10.1097/QAD.0000000000002022
[h=1]Increased influenza-specific antibody avidity in HIV-infected females compared to HIV-infected males on antiretroviral therapy.[/h] Luo Z[SUP]1[/SUP], Ogunrinde E[SUP]1[/SUP], Li M[SUP]1[/SUP], Zhang L[SUP]2[/SUP], Martin L[SUP]3[/SUP], Zhou Z[SUP]1[/SUP], Hu Z[SUP]1,[/SUP][SUP]4[/SUP], Zhang T[SUP]1,[/SUP][SUP]5[/SUP], Li Z[SUP]1,[/SUP][SUP]6[/SUP], Zhang J[SUP]1,[/SUP][SUP]7[/SUP], Su B[SUP]6[/SUP], Zhang T[SUP]6[/SUP], Wu H[SUP]6[/SUP], Ma L[SUP]8[/SUP], Liao G[SUP]8[/SUP], Eckard AR[SUP]3,[/SUP][SUP]9[/SUP], Westerink MAJ[SUP]3[/SUP], Heath S[SUP]10[/SUP], Jiang W[SUP]1,[/SUP][SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] : It is recommended that HIV-infected individuals receive annual influenza vaccination due to their high susceptibility to influenza infection, especially among females. However, there have been few studies investigating sex-related responses to influenza vaccine in antiretroviral (ART)-treated HIV-infected subjects. In this study, 26 aviremic ART-treated HIV-infected subjects and 16 healthy controls were enrolled in the current study. Blood was collected prior to vaccination (D0), on days 7-10 (D7), and on days 14-21 (D14) following administration of the 2013-2014 seasonal influenza vaccine. A series of analyses evaluated the serological and cellular responses following influenza vaccination. Female HIV-infected subjects had increased influenza-specific antibody avidity relative to male HIV-infected subjects, but similar plasma levels of influenza-specific binding antibodies and neutralizing antibodies. Increased cycling B cells and follicular helper CD4+ T (Tfh) cells were observed in female HIV-infected subjects pre- and post-vaccination compared to male HIV-infected subjects, and cycling Tfh cells were directly correlated with influenza-specific antibody avidity. Moreover, plasma testosterone levels were inversely correlated with antibody avidity index. The magnitude of microbial translocation (plasma lipopolysaccharide (LPS)) level was directly correlated with influenza-specific antibody avidity. Circulating 16S rDNA microbiome showed that enrichment of specific species within Proteobacteria was associated with influenza-specific antibody avidity. These results, including differences based on sex and correlations, were only observed in HIV+ subjects but not in the healthy controls. This study demonstrated sex differences in influenza-specific antibody avidity in ART-treated HIV disease, and provides valuable information on vaccination strategy in the ART-treated HIV-infected population.
PMID: 30234599 DOI: 10.1097/QAD.0000000000002022