tetano
Editor, Senior Moderator
J Infect Dis. 2016 Sep 21. pii: jiw448. [Epub ahead of print]
[h=1]Increased Pro-Inflammatory Responses of Monocytes and Plasmacytoid Dendritic Cells to Influenza A Virus Infection During Pregnancy.[/h] Le Gars M[SUP]1[/SUP], Kay AW[SUP]2[/SUP], Bayless NL[SUP]3[/SUP], Aziz N[SUP]4[/SUP], Dekker CL[SUP]2[/SUP], Swan GE[SUP]5[/SUP], Davis MM[SUP]6[/SUP], Blish CA[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Pregnancy-induced alterations in immunity may contribute to the increased morbidity associated with influenza A virus (IAV) infection during pregnancy. We characterized the immune response of monocytes and plasmacytoid dendritic cells (pDCs) to IAV infection in pregnant (n=21) and non-pregnant (n=21) women. In pregnant women, monocytes and pDCs exhibit an exaggerated pro-inflammatory immune response to two strains of IAV compared to non-pregnant women, characterized by increased expression of MHC class II (∼2.0-fold), CD69 (∼2.2-fold), interferon gamma induced protein 10 (IP-10, ∼2.0-fold) and macrophage inflammatory protein-1β (MIP-1β, ∼1.5-fold). This enhanced innate inflammatory response during pregnancy could contribute to pulmonary inflammation following IAV infection.
? The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.
PMID: 27655870 DOI: 10.1093/infdis/jiw448
[PubMed - as supplied by publisher]
[h=1]Increased Pro-Inflammatory Responses of Monocytes and Plasmacytoid Dendritic Cells to Influenza A Virus Infection During Pregnancy.[/h] Le Gars M[SUP]1[/SUP], Kay AW[SUP]2[/SUP], Bayless NL[SUP]3[/SUP], Aziz N[SUP]4[/SUP], Dekker CL[SUP]2[/SUP], Swan GE[SUP]5[/SUP], Davis MM[SUP]6[/SUP], Blish CA[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Pregnancy-induced alterations in immunity may contribute to the increased morbidity associated with influenza A virus (IAV) infection during pregnancy. We characterized the immune response of monocytes and plasmacytoid dendritic cells (pDCs) to IAV infection in pregnant (n=21) and non-pregnant (n=21) women. In pregnant women, monocytes and pDCs exhibit an exaggerated pro-inflammatory immune response to two strains of IAV compared to non-pregnant women, characterized by increased expression of MHC class II (∼2.0-fold), CD69 (∼2.2-fold), interferon gamma induced protein 10 (IP-10, ∼2.0-fold) and macrophage inflammatory protein-1β (MIP-1β, ∼1.5-fold). This enhanced innate inflammatory response during pregnancy could contribute to pulmonary inflammation following IAV infection.
? The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.
PMID: 27655870 DOI: 10.1093/infdis/jiw448
[PubMed - as supplied by publisher]