tetano
Editor, Senior Moderator
Indian J Crit Care Med
. 2022 Jan;26(1):39-42.
doi: 10.5005/jp-journals-10071-24075.
Interleukin 6 and Its Correlation with COVID-19 in Terms of Outcomes in an Intensive Care Unit of a Rural Hospital:A Cross-sectional Study
Dhruv Talwar[SUP] 1 [/SUP], Sunil Kumar[SUP] 1 [/SUP], Sourya Acharya[SUP] 1 [/SUP], Nitin Raisinghani[SUP] 1 [/SUP], Sparsh Madaan[SUP] 2 [/SUP], Vidyashree Hulkoti[SUP] 1 [/SUP], Annadatha Akhilesh[SUP] 1 [/SUP], Shivam Khanna[SUP] 1 [/SUP], Divit Shah[SUP] 1 [/SUP], Shubham Nimkar[SUP] 1 [/SUP]
Affiliations
Abstract
Background: Interleukin 6 (IL-6) encoded by the gene coded as IL 6 acts as a proinflammatory cytokine as well as an anti-inflammatory myokine. It is postulated that IL 6 is associated directly with the severity of coronavirus disease-2019 (COVID-19). Another domain that is thought to predict the severity of COVID-19 is the neutrophil:lymphocyte (N:L) ratio; a higher N:L ratio is postulated to be related to more severe outcomes. Thus, the present study was aimed to establish a correlation of COVID-19 with IL-6 in terms of clinical outcomes. We had also tried to find the relationship between IL-6 and N:L ratio and high-resolution computed tomography (HRCT) score.
Methods: We have conducted a cross-sectional study of 200 patients who were admitted to the intensive care unit (ICU) with reverse transcriptase-polymerase chain reaction (RT-PCR) positive for COVID-19 from January to May 2021. Serum IL-6, N:L ratio, and HRCT chest were conducted on admission.
Result: Out of 200 patients who were admitted to the ICU with COVID-19, while the IL-6 was higher in patients with increased N:L ratio and HRCT score, the association of IL-6 with clinical outcomes in terms of discharged and expired was found to be statistically not significant.
Conclusion: Serum IL-6 was found not to be a potent marker for clinical outcomes in ICU patients in terms of death vs survived. However, the IL-6 levels on admission can be correlated with the computed tomography (CT) severity scores as well as N:L ratio of patients admitted to an ICU.
How to cite this article: Talwar D, Kumar S, Acharya S, Raisinghani N, Madaan S, Hulkoti V, et al. Interleukin 6 and Its Correlation with COVID-19 in Terms of Outcomes in an Intensive Care Unit of a Rural Hospital: A Cross-sectional Study. Indian J Crit Care Med 2022;26(1):39-42.
Keywords: COVID-19; High-resolution computed tomography score; Interleukin 6; Neutrophil:lymphocyte ratio.
. 2022 Jan;26(1):39-42.
doi: 10.5005/jp-journals-10071-24075.
Interleukin 6 and Its Correlation with COVID-19 in Terms of Outcomes in an Intensive Care Unit of a Rural Hospital:A Cross-sectional Study
Dhruv Talwar[SUP] 1 [/SUP], Sunil Kumar[SUP] 1 [/SUP], Sourya Acharya[SUP] 1 [/SUP], Nitin Raisinghani[SUP] 1 [/SUP], Sparsh Madaan[SUP] 2 [/SUP], Vidyashree Hulkoti[SUP] 1 [/SUP], Annadatha Akhilesh[SUP] 1 [/SUP], Shivam Khanna[SUP] 1 [/SUP], Divit Shah[SUP] 1 [/SUP], Shubham Nimkar[SUP] 1 [/SUP]
Affiliations
- PMID: 35110842
- PMCID: PMC8783243
- DOI: 10.5005/jp-journals-10071-24075
Abstract
Background: Interleukin 6 (IL-6) encoded by the gene coded as IL 6 acts as a proinflammatory cytokine as well as an anti-inflammatory myokine. It is postulated that IL 6 is associated directly with the severity of coronavirus disease-2019 (COVID-19). Another domain that is thought to predict the severity of COVID-19 is the neutrophil:lymphocyte (N:L) ratio; a higher N:L ratio is postulated to be related to more severe outcomes. Thus, the present study was aimed to establish a correlation of COVID-19 with IL-6 in terms of clinical outcomes. We had also tried to find the relationship between IL-6 and N:L ratio and high-resolution computed tomography (HRCT) score.
Methods: We have conducted a cross-sectional study of 200 patients who were admitted to the intensive care unit (ICU) with reverse transcriptase-polymerase chain reaction (RT-PCR) positive for COVID-19 from January to May 2021. Serum IL-6, N:L ratio, and HRCT chest were conducted on admission.
Result: Out of 200 patients who were admitted to the ICU with COVID-19, while the IL-6 was higher in patients with increased N:L ratio and HRCT score, the association of IL-6 with clinical outcomes in terms of discharged and expired was found to be statistically not significant.
Conclusion: Serum IL-6 was found not to be a potent marker for clinical outcomes in ICU patients in terms of death vs survived. However, the IL-6 levels on admission can be correlated with the computed tomography (CT) severity scores as well as N:L ratio of patients admitted to an ICU.
How to cite this article: Talwar D, Kumar S, Acharya S, Raisinghani N, Madaan S, Hulkoti V, et al. Interleukin 6 and Its Correlation with COVID-19 in Terms of Outcomes in an Intensive Care Unit of a Rural Hospital: A Cross-sectional Study. Indian J Crit Care Med 2022;26(1):39-42.
Keywords: COVID-19; High-resolution computed tomography score; Interleukin 6; Neutrophil:lymphocyte ratio.