tetano
Editor, Senior Moderator
Nat Commun. 2019 Jan 10;10(1):106. doi: 10.1038/s41467-018-08036-6.
[h=1]Indirect protection from vaccinating children against influenza in households.[/h] Tsang TK[SUP]1,[/SUP][SUP]2[/SUP], Fang VJ[SUP]1[/SUP], Ip DKM[SUP]1[/SUP], Perera RAPM[SUP]1,[/SUP][SUP]3[/SUP], So HC[SUP]1[/SUP], Leung GM[SUP]1[/SUP], Peiris JSM[SUP]1,[/SUP][SUP]3[/SUP], Cowling BJ[SUP]4[/SUP], Cauchemez S[SUP]5,[/SUP][SUP]6,[/SUP][SUP]7[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Vaccination is an important intervention to prevent influenza virus infection, but indirect protection of household members of vaccinees is not fully known. Here, we analyze a cluster household randomized controlled trial, with one child in each household randomized to receive influenza vaccine or placebo, for an influenza B epidemic in Hong Kong. We apply statistical models to estimate household transmission dynamics and quantify the direct and indirect protection of vaccination. Direct vaccine efficacy was 71%. The infection probability of unvaccinated household members in vaccinated households was only 5% lower than in control households, because only 10% of infections are attributed to household transmission. Even when that proportion rises to 30% and all children are vaccinated, we predict that the infection probability for unvaccinated household members would only be reduced by 20%. This suggests that benefits of individual vaccination remain important even when other household members are vaccinated.
PMID: 30631062 DOI: 10.1038/s41467-018-08036-6
[h=1]Indirect protection from vaccinating children against influenza in households.[/h] Tsang TK[SUP]1,[/SUP][SUP]2[/SUP], Fang VJ[SUP]1[/SUP], Ip DKM[SUP]1[/SUP], Perera RAPM[SUP]1,[/SUP][SUP]3[/SUP], So HC[SUP]1[/SUP], Leung GM[SUP]1[/SUP], Peiris JSM[SUP]1,[/SUP][SUP]3[/SUP], Cowling BJ[SUP]4[/SUP], Cauchemez S[SUP]5,[/SUP][SUP]6,[/SUP][SUP]7[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Vaccination is an important intervention to prevent influenza virus infection, but indirect protection of household members of vaccinees is not fully known. Here, we analyze a cluster household randomized controlled trial, with one child in each household randomized to receive influenza vaccine or placebo, for an influenza B epidemic in Hong Kong. We apply statistical models to estimate household transmission dynamics and quantify the direct and indirect protection of vaccination. Direct vaccine efficacy was 71%. The infection probability of unvaccinated household members in vaccinated households was only 5% lower than in control households, because only 10% of infections are attributed to household transmission. Even when that proportion rises to 30% and all children are vaccinated, we predict that the infection probability for unvaccinated household members would only be reduced by 20%. This suggests that benefits of individual vaccination remain important even when other household members are vaccinated.
PMID: 30631062 DOI: 10.1038/s41467-018-08036-6