tetano
Editor, Senior Moderator
Infect Chemother
. 2021 Aug 30.
doi: 10.3947/ic.2021.0060. Online ahead of print.
A Meta-Analysis of Association between Remdesivir and Mortality among Critically-Ill COVID-19 Patients
Aminah Abdul Razzack[SUP] 1 [/SUP], Syed Adeel Hassan[SUP] 2 [/SUP], Sai Kumar Reddy Pasya[SUP] 3 [/SUP], Greeshma Erasani[SUP] 3 [/SUP], Sham Kumar[SUP] 4 [/SUP], Dario Missael Rocha-Castellanos[SUP] 5 [/SUP], Alfonso Lopez-Mendez[SUP] 6 [/SUP], Sarah Abdul Razzack[SUP] 3 [/SUP]
Affiliations
Abstract
Background: The World Health Organization guidelines did not make a recommendation on use of remdesivir based on disease severity. Little is known regarding effectiveness of remdesivir in critically ill coronavirus disease 2019 (COVID-19) patients. This has led to a state of dilemma for doctors leaving them skeptical of whether they should continue to recommend the drug or not.
Materials and methods: A systematic search adhering to preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines was conducted from inception until February 20, 2020. Electronic bibliographic databases (PubMed, Cochrane database, Scopus, Embase) were included. Using dichotomous data for select values, the unadjusted odds ratios (ORs) were calculated applying Mantel Haenszel (M-H) using random-effects model. The primary outcome of interest was all-cause mortality in ventilated and non-ventilated patients.
Results: The Remdesivir arm was associated with similar rates of 28-day all-cause mortality (OR: 0.93, 95% CI: 0.80 - 1.08; P = 0.33). Remdesivir was not found to be favorable for ventilated patients. Non ventilated COVID-19 patients showed a significant lower in-hospital mortality rate as compared with patients requiring mechanical ventilatory support (OR: 6.86, 95% CI: 5.39 - 268.74; P <0.0001).
Conclusion: Non-ventilated patients were associated with significant lower all-cause mortality rates. Prudent use of Remdesivir is recommended in critically ill COVID-19 patients.
Keywords: Antiviral therapy; COVID-19; Critical care; Remdesivir.
. 2021 Aug 30.
doi: 10.3947/ic.2021.0060. Online ahead of print.
A Meta-Analysis of Association between Remdesivir and Mortality among Critically-Ill COVID-19 Patients
Aminah Abdul Razzack[SUP] 1 [/SUP], Syed Adeel Hassan[SUP] 2 [/SUP], Sai Kumar Reddy Pasya[SUP] 3 [/SUP], Greeshma Erasani[SUP] 3 [/SUP], Sham Kumar[SUP] 4 [/SUP], Dario Missael Rocha-Castellanos[SUP] 5 [/SUP], Alfonso Lopez-Mendez[SUP] 6 [/SUP], Sarah Abdul Razzack[SUP] 3 [/SUP]
Affiliations
- PMID: 34508325
- DOI: 10.3947/ic.2021.0060
Abstract
Background: The World Health Organization guidelines did not make a recommendation on use of remdesivir based on disease severity. Little is known regarding effectiveness of remdesivir in critically ill coronavirus disease 2019 (COVID-19) patients. This has led to a state of dilemma for doctors leaving them skeptical of whether they should continue to recommend the drug or not.
Materials and methods: A systematic search adhering to preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines was conducted from inception until February 20, 2020. Electronic bibliographic databases (PubMed, Cochrane database, Scopus, Embase) were included. Using dichotomous data for select values, the unadjusted odds ratios (ORs) were calculated applying Mantel Haenszel (M-H) using random-effects model. The primary outcome of interest was all-cause mortality in ventilated and non-ventilated patients.
Results: The Remdesivir arm was associated with similar rates of 28-day all-cause mortality (OR: 0.93, 95% CI: 0.80 - 1.08; P = 0.33). Remdesivir was not found to be favorable for ventilated patients. Non ventilated COVID-19 patients showed a significant lower in-hospital mortality rate as compared with patients requiring mechanical ventilatory support (OR: 6.86, 95% CI: 5.39 - 268.74; P <0.0001).
Conclusion: Non-ventilated patients were associated with significant lower all-cause mortality rates. Prudent use of Remdesivir is recommended in critically ill COVID-19 patients.
Keywords: Antiviral therapy; COVID-19; Critical care; Remdesivir.