tetano
Editor, Senior Moderator
Infect Dis Rep
. 2022 Feb 21;14(1):142-154.
doi: 10.3390/idr14010018.
Vaccine-Induced Subacute Thyroiditis (De Quervain's) after mRNA Vaccine against SARS-CoV-2: A Case Report and Systematic Review
Giuseppe Pipitone[SUP] 1 2 [/SUP], Lorenzo Vittorio Rindi[SUP] 3 [/SUP], Nicola Petrosillo[SUP] 4 [/SUP], Nunzio Adalberto Maria Foti[SUP] 3 [/SUP], Grazia Caci[SUP] 5 [/SUP], Chiara Iaria[SUP] 2 [/SUP], Davide Roberto Donno[SUP] 1 [/SUP], Evangelo Boumis[SUP] 1 [/SUP], Giuseppe Paviglianiti[SUP] 6 [/SUP], Fabrizio Taglietti[SUP] 1 [/SUP]
Affiliations
Abstract
De Quervain's thyroiditis, sometimes referred to as subacute thyroiditis (SAT), is the most common granulomatous disease of the thyroid, typically found after a viral infection in middle-aged women. The mRNA encoding for the angiotensin-converting enzyme-2 (ACE-2) receptor is expressed in follicular thyroid cells, making them a potential target for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Besides infection, SARS-CoV-2 vaccines have also been implicated in SAT pathogenesis. We present a case of a woman developing SAT following vaccination with Comirnaty by Pfizer Inc. (New-York, USA). We performed a systematic review of similar cases available in the literature to provide a better understanding of the topic. We searched the databases PubMed and Embase and followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Patient records were then sorted according to the type of administered vaccine and a statistical analysis of the extracted data was performed. No statistically significant difference between mRNA vaccines and other vaccines in inducing SAT was found, nor was any found in terms of patient demographics, symptoms at presentation, initial, or follow-up blood tests. In our case report, we described the possible association between SARS-CoV-2 mRNA-based vaccine Comirnaty and SAT.
Keywords: ASIA syndrome; De Quervain; SARS-CoV-2 vaccine; thyroiditis.
. 2022 Feb 21;14(1):142-154.
doi: 10.3390/idr14010018.
Vaccine-Induced Subacute Thyroiditis (De Quervain's) after mRNA Vaccine against SARS-CoV-2: A Case Report and Systematic Review
Giuseppe Pipitone[SUP] 1 2 [/SUP], Lorenzo Vittorio Rindi[SUP] 3 [/SUP], Nicola Petrosillo[SUP] 4 [/SUP], Nunzio Adalberto Maria Foti[SUP] 3 [/SUP], Grazia Caci[SUP] 5 [/SUP], Chiara Iaria[SUP] 2 [/SUP], Davide Roberto Donno[SUP] 1 [/SUP], Evangelo Boumis[SUP] 1 [/SUP], Giuseppe Paviglianiti[SUP] 6 [/SUP], Fabrizio Taglietti[SUP] 1 [/SUP]
Affiliations
- PMID: 35200445
- DOI: 10.3390/idr14010018
Abstract
De Quervain's thyroiditis, sometimes referred to as subacute thyroiditis (SAT), is the most common granulomatous disease of the thyroid, typically found after a viral infection in middle-aged women. The mRNA encoding for the angiotensin-converting enzyme-2 (ACE-2) receptor is expressed in follicular thyroid cells, making them a potential target for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Besides infection, SARS-CoV-2 vaccines have also been implicated in SAT pathogenesis. We present a case of a woman developing SAT following vaccination with Comirnaty by Pfizer Inc. (New-York, USA). We performed a systematic review of similar cases available in the literature to provide a better understanding of the topic. We searched the databases PubMed and Embase and followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Patient records were then sorted according to the type of administered vaccine and a statistical analysis of the extracted data was performed. No statistically significant difference between mRNA vaccines and other vaccines in inducing SAT was found, nor was any found in terms of patient demographics, symptoms at presentation, initial, or follow-up blood tests. In our case report, we described the possible association between SARS-CoV-2 mRNA-based vaccine Comirnaty and SAT.
Keywords: ASIA syndrome; De Quervain; SARS-CoV-2 vaccine; thyroiditis.