tetano
Editor, Senior Moderator
Infect Drug Resist
. 2023 Jan 24;16:445-455.
doi: 10.2147/IDR.S398731. eCollection 2023.
Platelet-to-White Blood Cell Ratio as a Predictor of Mortality in Patients with Severe COVID-19 Pneumonia: A Retrospective Cohort Study
Metus Thungthienthong[SUP] 1 [/SUP], Veerapong Vattanavanit[SUP] 2 [/SUP]
Affiliations
Abstract
Purpose: Complete blood count (CBC) parameters are widely used as predictors of Coronavirus disease 2019 (COVID-19) severity. However, the clinical significance of these markers in severe COVID-19 pneumonia remains unclear. This study aimed to investigate the role of CBC parameters in predicting mortality in patients with severe COVID-19 pneumonia.
Patients and methods: We conducted a retrospective study at a tertiary care center in southern Thailand. Between January 2020 and December 2021, adult patients who had been diagnosed with severe COVID-19 pneumonia were enrolled. Demographic and clinical data, including CBC data on admission, were analyzed and compared between survivors and non-survivors.
Results: A total of 215 patients with severe COVID-19 pneumonia were enrolled. The in-hospital mortality was 29.3%. Non-survivors had a significantly lower platelet-to-white blood cell ratio (PWR) than survivors (15.8 vs 29.0, p < 0.001). PWR had the best accuracy in predicting in-hospital mortality, with an area under the curve (AUC) of the receiver operating characteristic curve of 0.801, followed by the CURB-65 of 0.789.
Conclusion: PWR appears to be a simple independent predictor of mortality in patients with severe COVID-19 pneumonia.
Keywords: COVID-19; mortality; platelet; pneumonia; white blood cell.
. 2023 Jan 24;16:445-455.
doi: 10.2147/IDR.S398731. eCollection 2023.
Platelet-to-White Blood Cell Ratio as a Predictor of Mortality in Patients with Severe COVID-19 Pneumonia: A Retrospective Cohort Study
Metus Thungthienthong[SUP] 1 [/SUP], Veerapong Vattanavanit[SUP] 2 [/SUP]
Affiliations
- PMID: 36718462
- PMCID: PMC9884061
- DOI: 10.2147/IDR.S398731
Abstract
Purpose: Complete blood count (CBC) parameters are widely used as predictors of Coronavirus disease 2019 (COVID-19) severity. However, the clinical significance of these markers in severe COVID-19 pneumonia remains unclear. This study aimed to investigate the role of CBC parameters in predicting mortality in patients with severe COVID-19 pneumonia.
Patients and methods: We conducted a retrospective study at a tertiary care center in southern Thailand. Between January 2020 and December 2021, adult patients who had been diagnosed with severe COVID-19 pneumonia were enrolled. Demographic and clinical data, including CBC data on admission, were analyzed and compared between survivors and non-survivors.
Results: A total of 215 patients with severe COVID-19 pneumonia were enrolled. The in-hospital mortality was 29.3%. Non-survivors had a significantly lower platelet-to-white blood cell ratio (PWR) than survivors (15.8 vs 29.0, p < 0.001). PWR had the best accuracy in predicting in-hospital mortality, with an area under the curve (AUC) of the receiver operating characteristic curve of 0.801, followed by the CURB-65 of 0.789.
Conclusion: PWR appears to be a simple independent predictor of mortality in patients with severe COVID-19 pneumonia.
Keywords: COVID-19; mortality; platelet; pneumonia; white blood cell.