tetano
Editor, Senior Moderator
Infect Drug Resist
. 2020 Jul 22;13:2485-2493.
doi: 10.2147/IDR.S258639. eCollection 2020.
Role of Monocytes/Macrophages in Covid-19 Pathogenesis: Implications for Therapy
Jose G?mez-Rial[SUP] 1 2 [/SUP], Irene Rivero-Calle[SUP] 1 3 [/SUP], Antonio Salas[SUP] 1 4 [/SUP], Federico Martin?n-Torres[SUP] 1 3 [/SUP]
Affiliations
Abstract
Emerging studies from SARS-CoV-2-infected patients indicate a preponderant role of monocytes/macrophages in the pathogenesis of this viral infection, in a similar way to that previously observed in other coronavirus outbreaks (SARS and MERS). The clinical presentation of severe patients resembles viral-associated hemophagocytic syndrome, a rare condition previously seen during lethal influenza pandemics and during previous SARS and MERS coronavirus outbreaks. SARS-CoV-2 infection triggers an over-exuberant inflammatory response due to the development of a cytokine storm and the depletion of the adaptative immune compartment, which may prelude sepsis in many cases. The present review summarizes past evidence on the role of monocytes/macrophages in previous coronavirus outbreaks and the emerging knowledge on their role in COVID-19 pathogenesis. Treatment strategies incorporating the blockade of migration and differentiation of monocyte-macrophage, such as granulocyte macrophage-colony stimulating factor inhibitors, might enhance the promising results seen so far with selective cytokine blockade.
Keywords: COVID-19 infection; anti-GM-CSF; coronavirus; monocyte/macrophage.
. 2020 Jul 22;13:2485-2493.
doi: 10.2147/IDR.S258639. eCollection 2020.
Role of Monocytes/Macrophages in Covid-19 Pathogenesis: Implications for Therapy
Jose G?mez-Rial[SUP] 1 2 [/SUP], Irene Rivero-Calle[SUP] 1 3 [/SUP], Antonio Salas[SUP] 1 4 [/SUP], Federico Martin?n-Torres[SUP] 1 3 [/SUP]
Affiliations
- PMID: 32801787
- PMCID: PMC7383015
- DOI: 10.2147/IDR.S258639
Abstract
Emerging studies from SARS-CoV-2-infected patients indicate a preponderant role of monocytes/macrophages in the pathogenesis of this viral infection, in a similar way to that previously observed in other coronavirus outbreaks (SARS and MERS). The clinical presentation of severe patients resembles viral-associated hemophagocytic syndrome, a rare condition previously seen during lethal influenza pandemics and during previous SARS and MERS coronavirus outbreaks. SARS-CoV-2 infection triggers an over-exuberant inflammatory response due to the development of a cytokine storm and the depletion of the adaptative immune compartment, which may prelude sepsis in many cases. The present review summarizes past evidence on the role of monocytes/macrophages in previous coronavirus outbreaks and the emerging knowledge on their role in COVID-19 pathogenesis. Treatment strategies incorporating the blockade of migration and differentiation of monocyte-macrophage, such as granulocyte macrophage-colony stimulating factor inhibitors, might enhance the promising results seen so far with selective cytokine blockade.
Keywords: COVID-19 infection; anti-GM-CSF; coronavirus; monocyte/macrophage.