tetano
Editor, Senior Moderator
Infect Genet Evol
. 2021 Aug 2;105013.
doi: 10.1016/j.meegid.2021.105013. Online ahead of print.
A discernable increase in the severe acute respiratory syndrome coronavirus 2 R.1 lineage carrying an E484K spike protein mutation in Japan
Tsuyoshi Sekizuka[SUP] 1 [/SUP], Kentaro Itokawa[SUP] 1 [/SUP], Masanori Hashino[SUP] 1 [/SUP], Kazuhiro Okubo[SUP] 2 [/SUP], Asami Ohnishi[SUP] 3 [/SUP], Keiko Goto[SUP] 4 [/SUP], Hiroyuki Tsukagoshi[SUP] 5 [/SUP], Hayato Ehara[SUP] 6 [/SUP], Ryohei Nomoto[SUP] 7 [/SUP], Makoto Ohnishi[SUP] 8 [/SUP], Makoto Kuroda[SUP] 9 [/SUP], Virus Diagnosis Group (NIID Toyama); COVID-19 Genomic Surveillance Network in Japan (COG-JP)
Affiliations
Abstract
Three COVID-19 waves in Japan have been characterized by the presence of distinct PANGO lineages (B.1.1. 162, B.1.1.284, and B.1.1.214). Recently, in addition to the B.1.1.7 lineage, which shows 25% abundance, an R.1 lineage carrying the E484K mutation in the spike protein was found to show up to 40% predominance. E484K could be a pivotal amino acid substitution with the potential to mediate immune escape; thus, more attention should be paid to such potential variants of concern to avoid the emergence of mutants of concern. Such comprehensive real-time genome surveillance has become essential for the containment of COVID-19 clusters.
Keywords: COVID-19; E484K; Immune escape; Mutation of concern; R.1; SARS-CoV-2; Spatiotemporal distribution; Spike protein.
. 2021 Aug 2;105013.
doi: 10.1016/j.meegid.2021.105013. Online ahead of print.
A discernable increase in the severe acute respiratory syndrome coronavirus 2 R.1 lineage carrying an E484K spike protein mutation in Japan
Tsuyoshi Sekizuka[SUP] 1 [/SUP], Kentaro Itokawa[SUP] 1 [/SUP], Masanori Hashino[SUP] 1 [/SUP], Kazuhiro Okubo[SUP] 2 [/SUP], Asami Ohnishi[SUP] 3 [/SUP], Keiko Goto[SUP] 4 [/SUP], Hiroyuki Tsukagoshi[SUP] 5 [/SUP], Hayato Ehara[SUP] 6 [/SUP], Ryohei Nomoto[SUP] 7 [/SUP], Makoto Ohnishi[SUP] 8 [/SUP], Makoto Kuroda[SUP] 9 [/SUP], Virus Diagnosis Group (NIID Toyama); COVID-19 Genomic Surveillance Network in Japan (COG-JP)
Affiliations
- PMID: 34352360
- DOI: 10.1016/j.meegid.2021.105013
Abstract
Three COVID-19 waves in Japan have been characterized by the presence of distinct PANGO lineages (B.1.1. 162, B.1.1.284, and B.1.1.214). Recently, in addition to the B.1.1.7 lineage, which shows 25% abundance, an R.1 lineage carrying the E484K mutation in the spike protein was found to show up to 40% predominance. E484K could be a pivotal amino acid substitution with the potential to mediate immune escape; thus, more attention should be paid to such potential variants of concern to avoid the emergence of mutants of concern. Such comprehensive real-time genome surveillance has become essential for the containment of COVID-19 clusters.
Keywords: COVID-19; E484K; Immune escape; Mutation of concern; R.1; SARS-CoV-2; Spatiotemporal distribution; Spike protein.