tetano
Editor, Senior Moderator
Infection
. 2023 Sep 13.
doi: 10.1007/s15010-023-02095-8. Online ahead of print. Clinical and epidemiological factors causing longer SARS-CoV 2 viral shedding: the results from the CoviCamp cohort
Pierantonio Grimaldi[SUP] #[/SUP][SUP] 1 [/SUP], Antonio Russo[SUP] #[/SUP][SUP] 1 [/SUP], Mariantonietta Pisaturo[SUP] 1 [/SUP], Paolo Maggi[SUP] 2 [/SUP], Enrico Allegorico[SUP] 3 [/SUP], Ivan Gentile[SUP] 4 [/SUP], Vincenzo Sangiovanni[SUP] 5 [/SUP], Annamaria Rossomando[SUP] 6 [/SUP], Rossella Pacilio[SUP] 7 [/SUP], Giosuele Calabria[SUP] 8 [/SUP], Raffaella Pisapia[SUP] 9 [/SUP], Canio Carriero[SUP] 10 [/SUP], Alfonso Masullo[SUP] 11 [/SUP], Elio Manzillo[SUP] 12 [/SUP], Grazia Russo[SUP] 13 [/SUP], Roberto Parrella[SUP] 14 [/SUP], Giuseppina Dell'Aquila[SUP] 15 [/SUP], Michele Gambardella[SUP] 16 [/SUP], Antonio Ponticiello[SUP] 17 [/SUP], Lorenzo Onorato[SUP] 1 [/SUP], Nicola Coppola[SUP] 18 [/SUP]; CoviCam group
Collaborators, Affiliations
Introduction: The aim of this study was to investigate how long hospitalized patients stayed positive to the nasopharyngeal swab, and what demographic and clinical factors influence the time-to-negative swab.
Methods: We enrolled in a multicenter, observational, retrospective study involving 17 COVID-19 units in eight cities of the Campania, southern Italy all patients hospitalized from March 2020 to May 2021 diagnosed with Severe Acute Respiratory Distress Syndrome-Coronavirus-2 (SARS-CoV-2) infection for whom time-to-negative swab was available.
Results: 963 patients were enrolled. We defined three groups considering time-to-negative swab: the first including patients with time-to-negative swab before the 26th day, the second including patients with time-to-negative swab from day 26 to day 39, and the third including patients with time-to-negative swab > 39 days. 721 (74.9%) patients belonged to the first group, 194 (20.1%) to the second, and 52 (5.4%) belonged to the third group. Belonging to group 2 and 3 seemed to be influenced by age (p value < 0.001), Charlson comorbidity index (p = 0.009), arterial hypertension (p = 0.02), cardiovascular disease (p = 0.017), or chronic kidney disease (CKD) (p = 0.001). The multivariable analysis confers a leading role to CKD, with an odds ratio of 2.3 as factor influencing belonging to the groups showing a longer time-to-negative swab. Patients with CKD and diabetes were more frequently in the third group.
Discussion: Our analysis showed that CKD is a factor related to longer time-to-negative swab, probably because of immunosuppression related to this condition.
Keywords: COVID-19; RT-PCR; SARS-CoV-2 infection; Time-to-negative swab; Viral shedding.
. 2023 Sep 13.
doi: 10.1007/s15010-023-02095-8. Online ahead of print. Clinical and epidemiological factors causing longer SARS-CoV 2 viral shedding: the results from the CoviCamp cohort
Pierantonio Grimaldi[SUP] #[/SUP][SUP] 1 [/SUP], Antonio Russo[SUP] #[/SUP][SUP] 1 [/SUP], Mariantonietta Pisaturo[SUP] 1 [/SUP], Paolo Maggi[SUP] 2 [/SUP], Enrico Allegorico[SUP] 3 [/SUP], Ivan Gentile[SUP] 4 [/SUP], Vincenzo Sangiovanni[SUP] 5 [/SUP], Annamaria Rossomando[SUP] 6 [/SUP], Rossella Pacilio[SUP] 7 [/SUP], Giosuele Calabria[SUP] 8 [/SUP], Raffaella Pisapia[SUP] 9 [/SUP], Canio Carriero[SUP] 10 [/SUP], Alfonso Masullo[SUP] 11 [/SUP], Elio Manzillo[SUP] 12 [/SUP], Grazia Russo[SUP] 13 [/SUP], Roberto Parrella[SUP] 14 [/SUP], Giuseppina Dell'Aquila[SUP] 15 [/SUP], Michele Gambardella[SUP] 16 [/SUP], Antonio Ponticiello[SUP] 17 [/SUP], Lorenzo Onorato[SUP] 1 [/SUP], Nicola Coppola[SUP] 18 [/SUP]; CoviCam group
Collaborators, Affiliations
- PMID: 37704910
- DOI: 10.1007/s15010-023-02095-8
Introduction: The aim of this study was to investigate how long hospitalized patients stayed positive to the nasopharyngeal swab, and what demographic and clinical factors influence the time-to-negative swab.
Methods: We enrolled in a multicenter, observational, retrospective study involving 17 COVID-19 units in eight cities of the Campania, southern Italy all patients hospitalized from March 2020 to May 2021 diagnosed with Severe Acute Respiratory Distress Syndrome-Coronavirus-2 (SARS-CoV-2) infection for whom time-to-negative swab was available.
Results: 963 patients were enrolled. We defined three groups considering time-to-negative swab: the first including patients with time-to-negative swab before the 26th day, the second including patients with time-to-negative swab from day 26 to day 39, and the third including patients with time-to-negative swab > 39 days. 721 (74.9%) patients belonged to the first group, 194 (20.1%) to the second, and 52 (5.4%) belonged to the third group. Belonging to group 2 and 3 seemed to be influenced by age (p value < 0.001), Charlson comorbidity index (p = 0.009), arterial hypertension (p = 0.02), cardiovascular disease (p = 0.017), or chronic kidney disease (CKD) (p = 0.001). The multivariable analysis confers a leading role to CKD, with an odds ratio of 2.3 as factor influencing belonging to the groups showing a longer time-to-negative swab. Patients with CKD and diabetes were more frequently in the third group.
Discussion: Our analysis showed that CKD is a factor related to longer time-to-negative swab, probably because of immunosuppression related to this condition.
Keywords: COVID-19; RT-PCR; SARS-CoV-2 infection; Time-to-negative swab; Viral shedding.