tetano
Editor, Senior Moderator
Inflamm Regen
. 2020 Aug 10;40(1):17.
doi: 10.1186/s41232-020-00126-7.
Genome evolution of SARS-CoV-2 and its virological characteristics
So Nakagawa[SUP] 1 2 3 [/SUP], Takayuki Miyazawa[SUP] 4 5 [/SUP]
Affiliations
Abstract
Coronavirus disease of 2019 (COVID-19), which originated in China in 2019, shows mild cold and pneumonia symptoms that can occasionally worsen and result in deaths. SARS-CoV-2 was reported to be the causative agent of the disease and was identified as being similar to SARS-CoV, a causative agent of SARS in 2003. In this review, we described the phylogeny of SARS-CoV-2, covering various related studies, in particular, focusing on viruses obtained from horseshoe bats and pangolins that belong to Sarbecovirus, a subgenus of Betacoronavirus. We also describe the virological characteristics of SARS-CoV-2 and compare them with other coronaviruses. More than 30,000 genome sequences of SARS-CoV-2 are available in the GISAID database as of May 28, 2020. Using the genome sequence data of closely related viruses, the genomic characteristics and evolution of SARS-CoV-2 were extensively studied. However, given the global prevalence of COVID-19 and the large number of associated deaths, further computational and experimental virological analyses are required to fully characterize SARS-CoV-2.
Keywords: COVID-19; Comparative genomics; Coronavirus; SARS-CoV-2; Viral evolution.
. 2020 Aug 10;40(1):17.
doi: 10.1186/s41232-020-00126-7.
Genome evolution of SARS-CoV-2 and its virological characteristics
So Nakagawa[SUP] 1 2 3 [/SUP], Takayuki Miyazawa[SUP] 4 5 [/SUP]
Affiliations
- PMID: 33349272
- DOI: 10.1186/s41232-020-00126-7
Abstract
Coronavirus disease of 2019 (COVID-19), which originated in China in 2019, shows mild cold and pneumonia symptoms that can occasionally worsen and result in deaths. SARS-CoV-2 was reported to be the causative agent of the disease and was identified as being similar to SARS-CoV, a causative agent of SARS in 2003. In this review, we described the phylogeny of SARS-CoV-2, covering various related studies, in particular, focusing on viruses obtained from horseshoe bats and pangolins that belong to Sarbecovirus, a subgenus of Betacoronavirus. We also describe the virological characteristics of SARS-CoV-2 and compare them with other coronaviruses. More than 30,000 genome sequences of SARS-CoV-2 are available in the GISAID database as of May 28, 2020. Using the genome sequence data of closely related viruses, the genomic characteristics and evolution of SARS-CoV-2 were extensively studied. However, given the global prevalence of COVID-19 and the large number of associated deaths, further computational and experimental virological analyses are required to fully characterize SARS-CoV-2.
Keywords: COVID-19; Comparative genomics; Coronavirus; SARS-CoV-2; Viral evolution.