tetano
Editor, Senior Moderator
Clin Exp Vaccine Res. 2014 Jan;3(1):5-11. Epub 2013 Dec 18.
Inflammasomes in antiviral immunity: clues for influenza vaccine development.
Yamazaki T, Ichinohe T.
Author information
Abstract
Inflammasomes are cytosolic multiprotein complexes that sense microbial motifs or cellular stress and stimulate caspase-1-dependent cytokine secretion and cell death. Recently, it has become increasingly evident that both DNA and RNA viruses activate inflammasomes, which control innate and adaptive immune responses against viral infections. In addition, recent studies suggest that certain microbiota induce inflammasomes-dependent adaptive immunity against influenza virus infections. Here, we review recent advances in research into the role of inflammasomes in antiviral immunity.
KEYWORDS:
Dendritic cells, Human NLRP3 protein, Metagenome, Orthomyxoviridae
PMID:
24427758
[PubMed - as supplied by publisher]
PMCID:
PMC3890450
Free PMC Article
http://www.ncbi.nlm.nih.gov/pubmed/24427758
Inflammasomes in antiviral immunity: clues for influenza vaccine development.
Yamazaki T, Ichinohe T.
Author information
Abstract
Inflammasomes are cytosolic multiprotein complexes that sense microbial motifs or cellular stress and stimulate caspase-1-dependent cytokine secretion and cell death. Recently, it has become increasingly evident that both DNA and RNA viruses activate inflammasomes, which control innate and adaptive immune responses against viral infections. In addition, recent studies suggest that certain microbiota induce inflammasomes-dependent adaptive immunity against influenza virus infections. Here, we review recent advances in research into the role of inflammasomes in antiviral immunity.
KEYWORDS:
Dendritic cells, Human NLRP3 protein, Metagenome, Orthomyxoviridae
PMID:
24427758
[PubMed - as supplied by publisher]
PMCID:
PMC3890450
Free PMC Article
http://www.ncbi.nlm.nih.gov/pubmed/24427758