tetano
Editor, Senior Moderator
Viruses. 2013 Jan 22;5(1):352-73. doi: 10.3390/v5010352.
Influenza a virus entry inhibitors targeting the hemagglutinin.
Yang J, Li M, Shen X, Liu S.
Source
School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China. liusw@smu.edu.cn.
Abstract
Influenza A virus (IAV) has caused seasonal influenza epidemics and influenza pandemics, which resulted in serious threat to public health and socioeconomic impacts. Until now, only 5 drugs belong to two categories are used for prophylaxis and treatment of IAV infection. Hemagglutinin (HA), the envelope glycoprotein of IAV, plays a critical role in viral binding, fusion and entry. Therefore, HA is an attractive target for developing anti‑IAV drugs to block the entry step of IAV infection. Here we reviewed the recent progress in the study of conformational changes of HA during viral fusion process and the development of HA-based IAV entry inhibitors, which may provide a new choice for controlling future influenza pandemics.
PMID:
23340380
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/23340380
Influenza a virus entry inhibitors targeting the hemagglutinin.
Yang J, Li M, Shen X, Liu S.
Source
School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China. liusw@smu.edu.cn.
Abstract
Influenza A virus (IAV) has caused seasonal influenza epidemics and influenza pandemics, which resulted in serious threat to public health and socioeconomic impacts. Until now, only 5 drugs belong to two categories are used for prophylaxis and treatment of IAV infection. Hemagglutinin (HA), the envelope glycoprotein of IAV, plays a critical role in viral binding, fusion and entry. Therefore, HA is an attractive target for developing anti‑IAV drugs to block the entry step of IAV infection. Here we reviewed the recent progress in the study of conformational changes of HA during viral fusion process and the development of HA-based IAV entry inhibitors, which may provide a new choice for controlling future influenza pandemics.
PMID:
23340380
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/23340380