tetano
Editor, Senior Moderator
Cell Host Microbe. 2014 Oct 23;16(5):691-700. doi: 10.1016/j.chom.2014.09.020. [Epub ahead of print]
Influenza A Virus Transmission Bottlenecks Are Defined by Infection Route and Recipient Host.
Varble A1, Albrecht RA1, Backes S1, Crumiller M2, Bouvier NM3, Sachs D4, Garc?a-Sastre A5, tenOever BR6.
Author information
Abstract
Despite its global relevance, our understanding of how influenza A virus transmission impacts the overall population dynamics of this RNA virus remains incomplete. To define this dynamic, we inserted neutral barcodes into the influenza A virus genome to generate a population of viruses that can be individually tracked during transmission events. We find that physiological bottlenecks differ dramatically based on the infection route and level of adaptation required for efficient replication. Strong genetic pressures are responsible for bottlenecks during adaptation across different host species, whereas transmission between susceptible hosts results in bottlenecks that are not genetically driven and occur at the level of the recipient. Additionally, the infection route significantly influences the bottleneck stringency, with aerosol transmission imposing greater selection than direct contact. These transmission constraints have implications in understanding the global migration of virus populations and provide a clearer perspective on the emergence of pandemic strains.
Copyright ? 2014 Elsevier Inc. All rights reserved.
PMID:
25456074
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25456074
Influenza A Virus Transmission Bottlenecks Are Defined by Infection Route and Recipient Host.
Varble A1, Albrecht RA1, Backes S1, Crumiller M2, Bouvier NM3, Sachs D4, Garc?a-Sastre A5, tenOever BR6.
Author information
Abstract
Despite its global relevance, our understanding of how influenza A virus transmission impacts the overall population dynamics of this RNA virus remains incomplete. To define this dynamic, we inserted neutral barcodes into the influenza A virus genome to generate a population of viruses that can be individually tracked during transmission events. We find that physiological bottlenecks differ dramatically based on the infection route and level of adaptation required for efficient replication. Strong genetic pressures are responsible for bottlenecks during adaptation across different host species, whereas transmission between susceptible hosts results in bottlenecks that are not genetically driven and occur at the level of the recipient. Additionally, the infection route significantly influences the bottleneck stringency, with aerosol transmission imposing greater selection than direct contact. These transmission constraints have implications in understanding the global migration of virus populations and provide a clearer perspective on the emergence of pandemic strains.
Copyright ? 2014 Elsevier Inc. All rights reserved.
PMID:
25456074
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25456074