tetano
Editor, Senior Moderator
J Infect. 2013 Mar 5. pii: S0163-4453(13)00042-X. doi: 10.1016/j.jinf.2013.02.007. [Epub ahead of print]
Influenza and RSV make a modest contribution to invasive pneumococcal disease incidence in the UK.
Nicoli EJ, Trotter CL, Turner KM, Colijn C, Waight P, Miller E.
Source
School of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol, UK, BS8 2PS. Electronic address: E.Nicoli@bristol.ac.uk.
Abstract
OBJECTIVES:
The common seasonality of incidence of invasive pneumococcal disease (IPD) and viral respiratory infections has long been recognized, however, the extent to which this affects the association between the pathogens is unknown. We have analyzed weekly surveillance data of IPD, influenza and respiratory syncytial virus (RSV), using ambient temperature and hours of sunshine as measures of seasonality.
METHODS:
Reported cases of influenza, IPD and RSV, were collected in England and Wales, from week 1 (January) 1996 to week 23 (June) 2009. The associations between IPD and respiratory viral infections were analyzed using several statistical methods, including correlation coefficients and both additive and multiplicative regression models.
RESULTS:
6 - 7.5% of cases of IPD are attributable to influenza and 3 - 4% attributable to RSV. Correlation coefficients reported considerably stronger associations between IPD and the viral infections compared to regression models.
CONCLUSIONS:
A small but potentially important percentage of IPD may be attributable to influenza and RSV when adjusted for seasonality by temperature. Jointly these viral infections may lead to over 10% of IPD cases. Therefore, prevention of viral respiratory infections may offer some additional benefit in reducing invasive pneumococcal infections.
Copyright ? 2013. Published by Elsevier Ltd.
PMID:
23473714
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23473714
Influenza and RSV make a modest contribution to invasive pneumococcal disease incidence in the UK.
Nicoli EJ, Trotter CL, Turner KM, Colijn C, Waight P, Miller E.
Source
School of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol, UK, BS8 2PS. Electronic address: E.Nicoli@bristol.ac.uk.
Abstract
OBJECTIVES:
The common seasonality of incidence of invasive pneumococcal disease (IPD) and viral respiratory infections has long been recognized, however, the extent to which this affects the association between the pathogens is unknown. We have analyzed weekly surveillance data of IPD, influenza and respiratory syncytial virus (RSV), using ambient temperature and hours of sunshine as measures of seasonality.
METHODS:
Reported cases of influenza, IPD and RSV, were collected in England and Wales, from week 1 (January) 1996 to week 23 (June) 2009. The associations between IPD and respiratory viral infections were analyzed using several statistical methods, including correlation coefficients and both additive and multiplicative regression models.
RESULTS:
6 - 7.5% of cases of IPD are attributable to influenza and 3 - 4% attributable to RSV. Correlation coefficients reported considerably stronger associations between IPD and the viral infections compared to regression models.
CONCLUSIONS:
A small but potentially important percentage of IPD may be attributable to influenza and RSV when adjusted for seasonality by temperature. Jointly these viral infections may lead to over 10% of IPD cases. Therefore, prevention of viral respiratory infections may offer some additional benefit in reducing invasive pneumococcal infections.
Copyright ? 2013. Published by Elsevier Ltd.
PMID:
23473714
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23473714