tetano
Editor, Senior Moderator
PLoS One. 2015 Sep 23;10(9):e0138708. doi: 10.1371/journal.pone.0138708.
[h=1]Influenza-Associated Disease Burden in Kenya: A Systematic Review of Literature.[/h] Emukule GO[SUP]1[/SUP], Paget J[SUP]2[/SUP], Velden KV[SUP]3[/SUP], Mott JA[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] In Kenya data on the burden of influenza disease are needed to inform influenza control policies.
[h=4]METHODS:[/h] We conducted a systematic review of published data describing the influenza disease burden in Kenya using surveillance data collected until December 2013. We included studies with laboratory confirmation of influenza, well-defined catchment populations, case definitions used to sample patients for testing and a description of the laboratory methods used for influenza testing. Studies with or without any adjustments on the incidence rates were included.
[h=4]RESULTS:[/h] Ten studies reporting the incidence of medically-attended and non-medically attended influenza were reviewed. For all age groups, the influenza positive proportion ranged from 5-10% among hospitalized patients, and 5-27% among all medically-attended patients (a combination of in- and outpatients). The adjusted incidence rate of hospitalizations with influenza among children <5 years ranged from 2.7-4.7 per 1,000 [5.7 per 1,000 in children <6 months old], and were 7-10 times higher compared to persons aged ≥5 years. The adjusted incidence of all medically-attended influenza among children aged <5 years ranged from 13.0-58.0 per 1,000 compared to 4.3-26.0 per 1,000 among persons aged ≥5 years.
[h=4]CONCLUSIONS:[/h] Our review shows an expanding set of literature on disease burden associated with influenza in Kenya, with a substantial burden in children under five years of age. Hospitalizations with influenza in these children were 2-3 times higher than reported in the United States. These findings highlight the possible value of an influenza vaccination program in Kenya, with children <5 years and pregnant women being potentially important targets.
PMID: 26398196 [PubMed - as supplied by publisher] Free full text
[h=1]Influenza-Associated Disease Burden in Kenya: A Systematic Review of Literature.[/h] Emukule GO[SUP]1[/SUP], Paget J[SUP]2[/SUP], Velden KV[SUP]3[/SUP], Mott JA[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] In Kenya data on the burden of influenza disease are needed to inform influenza control policies.
[h=4]METHODS:[/h] We conducted a systematic review of published data describing the influenza disease burden in Kenya using surveillance data collected until December 2013. We included studies with laboratory confirmation of influenza, well-defined catchment populations, case definitions used to sample patients for testing and a description of the laboratory methods used for influenza testing. Studies with or without any adjustments on the incidence rates were included.
[h=4]RESULTS:[/h] Ten studies reporting the incidence of medically-attended and non-medically attended influenza were reviewed. For all age groups, the influenza positive proportion ranged from 5-10% among hospitalized patients, and 5-27% among all medically-attended patients (a combination of in- and outpatients). The adjusted incidence rate of hospitalizations with influenza among children <5 years ranged from 2.7-4.7 per 1,000 [5.7 per 1,000 in children <6 months old], and were 7-10 times higher compared to persons aged ≥5 years. The adjusted incidence of all medically-attended influenza among children aged <5 years ranged from 13.0-58.0 per 1,000 compared to 4.3-26.0 per 1,000 among persons aged ≥5 years.
[h=4]CONCLUSIONS:[/h] Our review shows an expanding set of literature on disease burden associated with influenza in Kenya, with a substantial burden in children under five years of age. Hospitalizations with influenza in these children were 2-3 times higher than reported in the United States. These findings highlight the possible value of an influenza vaccination program in Kenya, with children <5 years and pregnant women being potentially important targets.
PMID: 26398196 [PubMed - as supplied by publisher] Free full text