tetano
Editor, Senior Moderator
Vaccine. 2019 Sep 11. pii: S0264-410X(19)31091-6. doi: 10.1016/j.vaccine.2019.08.027. [Epub ahead of print]
[h=1]Influenza B virus infections in Western Saxony, Germany in three consecutive seasons between 2015 and 2018: Analysis of molecular and clinical features.[/h] H?nemann M[SUP]1[/SUP], Martin D[SUP]2[/SUP], Pietsch C[SUP]2[/SUP], Maier M[SUP]2[/SUP], Bergs S[SUP]2[/SUP], Bieck E[SUP]3[/SUP], Liebert UG[SUP]2[/SUP].
[h=3]Author information[/h] 1 Institute of Virology, Leipzig University, Johannisallee 30, 04103 Leipzig, Germany. Electronic address: Mario.Hoenemann@medizin.uni-leipzig.de. 2 Institute of Virology, Leipzig University, Johannisallee 30, 04103 Leipzig, Germany. 3 Kreiskrankenhaus Torgau "J. Kentmann" gGmbH, 04860 Torgau, Germany.
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] The impact of annual influenza epidemics and prevailing strains varies worldwide and regional. The majority of vaccines used contained two influenza A strains and only one influenza B strain (trivalent vaccine).
[h=4]AIM:[/h] The aim of the study was to compare laboratory confirmed influenza B cases during three consecutive years with respect to vaccination history, clinical symptoms and molecular virology.
[h=4]METHODS:[/h] Partial HA gene sequences were analyzed for lineage determination and complete HA sequence in cases with reported vaccination and in fatal cases. Clinical data were retrieved from patient charts.
[h=4]FINDINGS:[/h] During the 2015/16 season, 75 influenza B cases were retrieved; 11 in 2016/17, and 274 in 2017/18. The frequency of Yamagata-lineage strains increased from 7.6% to 100%. No difference was detected in the relative frequency of co-morbidities in season 2017/18. 37.7% of the adult patients and 4.5% of pediatric patients were vaccinated against influenza.
[h=4]INTERPRETATION:[/h] Phylogenetically, Yamagata strains clustered similarly in 2017/2018 when compared to the previous two influenza seasons. While the relative frequency of influenza B cases differed, the clinical symptoms remained similar.
[h=4]CONCLUSION:[/h] World Health Organization recommendations for the use of tetravalent vaccines that contain two influenza B strains (Yamagata and Victoria) in addition to the two influenza A strains (H1N1 and H3N2) should be implemented in national vaccination guidelines.
[h=4]FUNDING:[/h] This research was partially supported by the Association of Sponsors and Friends of Leipzig University.
Copyright ? 2019 Elsevier Ltd. All rights reserved.
[h=4]KEYWORDS:[/h] Epidemiology; Influenza; Influenza B; Molecular epidemiology; Seasonal frequency; Victoria-like strains; Yamagata-like strains
PMID: 31521415 DOI: 10.1016/j.vaccine.2019.08.027
[h=1]Influenza B virus infections in Western Saxony, Germany in three consecutive seasons between 2015 and 2018: Analysis of molecular and clinical features.[/h] H?nemann M[SUP]1[/SUP], Martin D[SUP]2[/SUP], Pietsch C[SUP]2[/SUP], Maier M[SUP]2[/SUP], Bergs S[SUP]2[/SUP], Bieck E[SUP]3[/SUP], Liebert UG[SUP]2[/SUP].
[h=3]Author information[/h] 1 Institute of Virology, Leipzig University, Johannisallee 30, 04103 Leipzig, Germany. Electronic address: Mario.Hoenemann@medizin.uni-leipzig.de. 2 Institute of Virology, Leipzig University, Johannisallee 30, 04103 Leipzig, Germany. 3 Kreiskrankenhaus Torgau "J. Kentmann" gGmbH, 04860 Torgau, Germany.
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] The impact of annual influenza epidemics and prevailing strains varies worldwide and regional. The majority of vaccines used contained two influenza A strains and only one influenza B strain (trivalent vaccine).
[h=4]AIM:[/h] The aim of the study was to compare laboratory confirmed influenza B cases during three consecutive years with respect to vaccination history, clinical symptoms and molecular virology.
[h=4]METHODS:[/h] Partial HA gene sequences were analyzed for lineage determination and complete HA sequence in cases with reported vaccination and in fatal cases. Clinical data were retrieved from patient charts.
[h=4]FINDINGS:[/h] During the 2015/16 season, 75 influenza B cases were retrieved; 11 in 2016/17, and 274 in 2017/18. The frequency of Yamagata-lineage strains increased from 7.6% to 100%. No difference was detected in the relative frequency of co-morbidities in season 2017/18. 37.7% of the adult patients and 4.5% of pediatric patients were vaccinated against influenza.
[h=4]INTERPRETATION:[/h] Phylogenetically, Yamagata strains clustered similarly in 2017/2018 when compared to the previous two influenza seasons. While the relative frequency of influenza B cases differed, the clinical symptoms remained similar.
[h=4]CONCLUSION:[/h] World Health Organization recommendations for the use of tetravalent vaccines that contain two influenza B strains (Yamagata and Victoria) in addition to the two influenza A strains (H1N1 and H3N2) should be implemented in national vaccination guidelines.
[h=4]FUNDING:[/h] This research was partially supported by the Association of Sponsors and Friends of Leipzig University.
Copyright ? 2019 Elsevier Ltd. All rights reserved.
[h=4]KEYWORDS:[/h] Epidemiology; Influenza; Influenza B; Molecular epidemiology; Seasonal frequency; Victoria-like strains; Yamagata-like strains
PMID: 31521415 DOI: 10.1016/j.vaccine.2019.08.027