tetano
Editor, Senior Moderator
Protein Eng Des Sel. 2016 Jun 16. pii: gzw017. [Epub ahead of print]
[h=1]Influenza evolution and H3N2 vaccine effectiveness, with application to the 2014/2015 season.[/h] Li X[SUP]1[/SUP], Deem MW[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Influenza A is a serious disease that causes significant morbidity and mortality, and vaccines against the seasonal influenza disease are of variable effectiveness. In this article, we discuss the use of the p[SUB]epitope[/SUB] method to predict the dominant influenza strain and the expected vaccine effectiveness in the coming flu season. We illustrate how the effectiveness of the 2014/2015 A/Texas/50/2012 [clade 3C.1] vaccine against the A/California/02/2014 [clade 3C.3a] strain that emerged in the population can be estimated via p[SUB]epitope[/SUB] In addition, we show by a multidimensional scaling analysis of data collected through 2014, the emergence of a new A/New Mexico/11/2014-like cluster [clade 3C.2a] that is immunologically distinct from the A/California/02/2014-like strains.
? The Author 2016. Published by Oxford University Press.
[h=4]KEYWORDS:[/h] dominant strains; influenza evolution; pepitope; phylogeny; vaccine effectiveness
PMID: 27313229 [PubMed - as supplied by publisher] Free full text
[h=1]Influenza evolution and H3N2 vaccine effectiveness, with application to the 2014/2015 season.[/h] Li X[SUP]1[/SUP], Deem MW[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Influenza A is a serious disease that causes significant morbidity and mortality, and vaccines against the seasonal influenza disease are of variable effectiveness. In this article, we discuss the use of the p[SUB]epitope[/SUB] method to predict the dominant influenza strain and the expected vaccine effectiveness in the coming flu season. We illustrate how the effectiveness of the 2014/2015 A/Texas/50/2012 [clade 3C.1] vaccine against the A/California/02/2014 [clade 3C.3a] strain that emerged in the population can be estimated via p[SUB]epitope[/SUB] In addition, we show by a multidimensional scaling analysis of data collected through 2014, the emergence of a new A/New Mexico/11/2014-like cluster [clade 3C.2a] that is immunologically distinct from the A/California/02/2014-like strains.
? The Author 2016. Published by Oxford University Press.
[h=4]KEYWORDS:[/h] dominant strains; influenza evolution; pepitope; phylogeny; vaccine effectiveness
PMID: 27313229 [PubMed - as supplied by publisher] Free full text