tetano
Editor, Senior Moderator
Influenza Other Respir Viruses
. 2023 Aug 13;17(8):e13175.
doi: 10.1111/irv.13175. eCollection 2023 Aug. Influenza-associated respiratory illness among five cohorts of pregnant women and their young infants (0-6 months), Bangladesh, 2013-2017
Zubair Akhtar[SUP] 1 [/SUP], Probir Ghosh[SUP] 1 [/SUP], Mejbah Bhuiyan[SUP] 2 [/SUP], Katharine Sturm-Ramirez[SUP] 3 [/SUP], Mohammed Rahman[SUP] 1 [/SUP], Md Howlader[SUP] 1 [/SUP], Fatimah Dawood[SUP] 3 [/SUP], Fahmida Chowdhury[SUP] 1 [/SUP], Danielle Iuliano[SUP] 3 4 [/SUP]
Affiliations
Background: Pregnant women with their infants are considered at higher risk for influenza-associated complications, and the World Health Organization (WHO) recommends influenza vaccination during pregnancy to protect them, including their infants (0-6 months). There are limited data on the influenza burden among pregnant women and their infants (0-6 months), and there are no routine influenza vaccinations in Bangladesh.
Methods: Five annual cohorts (2013-2017) of pregnant women were enrolled from the eight sub-districts of Bangladesh before the influenza season (May-September); they were contacted weekly to identify new onset of influenza-like illness (ILI) (subjective or measured fever and cough) and acute respiratory illness (ARI) (at least two of these symptoms: cough, rhinorrhea, or difficulty in breathing) among their infants from birth to 6 months of age. We collected nasopharyngeal swabs from ILI and ARI cases, tested by real-time reverse transcription polymerase chain reaction (rRT-PCR) for influenza virus (including types and subtypes) and estimated influenza incidence (95% CI)/10000 pregnant women-months or infant-months, respectively.
Results: We enrolled 9020 pregnant women, followed for 26,709 pregnancy-months, and detected 1241 ILI episodes. We also followed 8963 infants for 51,518 infant-months and identified 5116 ARI episodes. Influenza positivity was 23% for ILI and 3% for ARI cases. The overall incidence (2013-2017) of influenza among pregnant women was 158.5/10000 pregnant women-months (95% CI: 141.4-177.6) and that among infants was 21.9/10000 infant-months (95% CI: 18.2-26.5).
Conclusions: Although the data was collected more than 5 years ago, as the only baseline data, our findings illustrate evidence of influenza burden among pregnant women and infants (0-6 months), which may support preventive policy decisions in Bangladesh.
Keywords: 0–6 months infant influenza; LMP; maternal influenza; portable ultrasound; pregnancy.
. 2023 Aug 13;17(8):e13175.
doi: 10.1111/irv.13175. eCollection 2023 Aug. Influenza-associated respiratory illness among five cohorts of pregnant women and their young infants (0-6 months), Bangladesh, 2013-2017
Zubair Akhtar[SUP] 1 [/SUP], Probir Ghosh[SUP] 1 [/SUP], Mejbah Bhuiyan[SUP] 2 [/SUP], Katharine Sturm-Ramirez[SUP] 3 [/SUP], Mohammed Rahman[SUP] 1 [/SUP], Md Howlader[SUP] 1 [/SUP], Fatimah Dawood[SUP] 3 [/SUP], Fahmida Chowdhury[SUP] 1 [/SUP], Danielle Iuliano[SUP] 3 4 [/SUP]
Affiliations
- PMID: 37583917
- PMCID: PMC10423715
- DOI: 10.1111/irv.13175
Background: Pregnant women with their infants are considered at higher risk for influenza-associated complications, and the World Health Organization (WHO) recommends influenza vaccination during pregnancy to protect them, including their infants (0-6 months). There are limited data on the influenza burden among pregnant women and their infants (0-6 months), and there are no routine influenza vaccinations in Bangladesh.
Methods: Five annual cohorts (2013-2017) of pregnant women were enrolled from the eight sub-districts of Bangladesh before the influenza season (May-September); they were contacted weekly to identify new onset of influenza-like illness (ILI) (subjective or measured fever and cough) and acute respiratory illness (ARI) (at least two of these symptoms: cough, rhinorrhea, or difficulty in breathing) among their infants from birth to 6 months of age. We collected nasopharyngeal swabs from ILI and ARI cases, tested by real-time reverse transcription polymerase chain reaction (rRT-PCR) for influenza virus (including types and subtypes) and estimated influenza incidence (95% CI)/10000 pregnant women-months or infant-months, respectively.
Results: We enrolled 9020 pregnant women, followed for 26,709 pregnancy-months, and detected 1241 ILI episodes. We also followed 8963 infants for 51,518 infant-months and identified 5116 ARI episodes. Influenza positivity was 23% for ILI and 3% for ARI cases. The overall incidence (2013-2017) of influenza among pregnant women was 158.5/10000 pregnant women-months (95% CI: 141.4-177.6) and that among infants was 21.9/10000 infant-months (95% CI: 18.2-26.5).
Conclusions: Although the data was collected more than 5 years ago, as the only baseline data, our findings illustrate evidence of influenza burden among pregnant women and infants (0-6 months), which may support preventive policy decisions in Bangladesh.
Keywords: 0–6 months infant influenza; LMP; maternal influenza; portable ultrasound; pregnancy.