tetano
Editor, Senior Moderator
Influenza Other Respir Viruses
. 2024 Jul;18(7):e13343.
doi: 10.1111/irv.13343. Seroprevalence of SARS-CoV-2 Antibodies and Associated Factors in Bamako, Mali: A Population-Based Cross-Sectional Study in September 2022
Bourama Traoré[SUP] 1 [/SUP], Merepen A Guindo[SUP] 1 [/SUP], Drissa Konaté[SUP] 1 [/SUP], Fousseyni Kané[SUP] 1 [/SUP], Nathan C Incandela[SUP] 2 [/SUP], Abdouramane Traore[SUP] 1 [/SUP], Salimata Kanté[SUP] 1 [/SUP], Mariam Sidibé[SUP] 1 [/SUP], Bourama Keita[SUP] 1 [/SUP], Fatoumata Kasse[SUP] 1 [/SUP], Karamoko Tangara[SUP] 1 [/SUP], Dramane Diallo[SUP] 1 [/SUP], Issoufi Y Maiga[SUP] 1 [/SUP], Salif Thiam[SUP] 1 [/SUP], Abdourhamane Cisse[SUP] 1 [/SUP], Khatry M Siby[SUP] 1 [/SUP], Abdoul R Dicko[SUP] 3 [/SUP], Mariam Goita[SUP] 3 [/SUP], Diakaridia Kone[SUP] 4 [/SUP], Mamadou Diallo[SUP] 5 [/SUP], Modibo Traore[SUP] 6 [/SUP], Yaya I Coulibaly[SUP] 1 [/SUP], Mahamadou Diakité[SUP] 1 [/SUP], Seydou Doumbia[SUP] 1 [/SUP], Housseini Dolo[SUP] 1 [/SUP], Saidou Balam[SUP] 1 [/SUP]
Affiliations
Background: The sero-epidemiological characteristics of SARS-CoV-2 infections in Mali are not yet well understood. This study assessed SARS-CoV-2 antibody seroprevalence and factors associated with antibody responses in the general population of Bamako, the capital city and epicenter of COVID-19, to assess the magnitude of the pandemic and contribute to control strategy improvements in Mali.
Methods: A cross-sectional survey was conducted in September 2022 to collect sociodemographic information, clinical characteristics, comorbid factors, and blood samples. ELISA was performed to determine anti-Spike (anti-S) and anti-RBD antibody levels. A total of 3601 participants were enrolled in REDCap. R-Studio was used for the statistical analysis. The chi-squared (χ[SUP]2[/SUP]) test was used to compare the proportions across different groups. Logistic regression models were used to elucidate factors associated with antibody responses.
Result: The sex ratio for female-to-male was 3.6:1. The most representative groups were the 20-29-year-olds (28.9%, n = 1043) and the 30-39-year-olds (26.9%, n = 967). The COVID-19 vaccine coverage among the participants was 35.8%, with vaccines from Covishield AstraZeneca (13.4%), Johnson & Johnson (16.7%), Sinovac (3.9%), and BioNTech Pfizer (1.8%). Overall, S protein and RBD antibody seroprevalences were remarkably high in the study population (98% and 97%, respectively). Factors such as youth (1-9 years old) and male sex were associated with lower SARS-CoV-2 antibody responses, whereas COVID-19 vaccinations were associated with increased antibody responses.
Conclusion: This serosurvey demonstrated the high seroprevalence of SARS-CoV-2 antibodies and highlighted the factors influencing antibody responses, while clearly underlining an underestimation of the pandemic in Mali.
Keywords: Bamako; Mali; SARS‐CoV‐2 antibodies; associated factors; seroprevalence.
. 2024 Jul;18(7):e13343.
doi: 10.1111/irv.13343. Seroprevalence of SARS-CoV-2 Antibodies and Associated Factors in Bamako, Mali: A Population-Based Cross-Sectional Study in September 2022
Bourama Traoré[SUP] 1 [/SUP], Merepen A Guindo[SUP] 1 [/SUP], Drissa Konaté[SUP] 1 [/SUP], Fousseyni Kané[SUP] 1 [/SUP], Nathan C Incandela[SUP] 2 [/SUP], Abdouramane Traore[SUP] 1 [/SUP], Salimata Kanté[SUP] 1 [/SUP], Mariam Sidibé[SUP] 1 [/SUP], Bourama Keita[SUP] 1 [/SUP], Fatoumata Kasse[SUP] 1 [/SUP], Karamoko Tangara[SUP] 1 [/SUP], Dramane Diallo[SUP] 1 [/SUP], Issoufi Y Maiga[SUP] 1 [/SUP], Salif Thiam[SUP] 1 [/SUP], Abdourhamane Cisse[SUP] 1 [/SUP], Khatry M Siby[SUP] 1 [/SUP], Abdoul R Dicko[SUP] 3 [/SUP], Mariam Goita[SUP] 3 [/SUP], Diakaridia Kone[SUP] 4 [/SUP], Mamadou Diallo[SUP] 5 [/SUP], Modibo Traore[SUP] 6 [/SUP], Yaya I Coulibaly[SUP] 1 [/SUP], Mahamadou Diakité[SUP] 1 [/SUP], Seydou Doumbia[SUP] 1 [/SUP], Housseini Dolo[SUP] 1 [/SUP], Saidou Balam[SUP] 1 [/SUP]
Affiliations
- PMID: 39044355
- DOI: 10.1111/irv.13343
Background: The sero-epidemiological characteristics of SARS-CoV-2 infections in Mali are not yet well understood. This study assessed SARS-CoV-2 antibody seroprevalence and factors associated with antibody responses in the general population of Bamako, the capital city and epicenter of COVID-19, to assess the magnitude of the pandemic and contribute to control strategy improvements in Mali.
Methods: A cross-sectional survey was conducted in September 2022 to collect sociodemographic information, clinical characteristics, comorbid factors, and blood samples. ELISA was performed to determine anti-Spike (anti-S) and anti-RBD antibody levels. A total of 3601 participants were enrolled in REDCap. R-Studio was used for the statistical analysis. The chi-squared (χ[SUP]2[/SUP]) test was used to compare the proportions across different groups. Logistic regression models were used to elucidate factors associated with antibody responses.
Result: The sex ratio for female-to-male was 3.6:1. The most representative groups were the 20-29-year-olds (28.9%, n = 1043) and the 30-39-year-olds (26.9%, n = 967). The COVID-19 vaccine coverage among the participants was 35.8%, with vaccines from Covishield AstraZeneca (13.4%), Johnson & Johnson (16.7%), Sinovac (3.9%), and BioNTech Pfizer (1.8%). Overall, S protein and RBD antibody seroprevalences were remarkably high in the study population (98% and 97%, respectively). Factors such as youth (1-9 years old) and male sex were associated with lower SARS-CoV-2 antibody responses, whereas COVID-19 vaccinations were associated with increased antibody responses.
Conclusion: This serosurvey demonstrated the high seroprevalence of SARS-CoV-2 antibodies and highlighted the factors influencing antibody responses, while clearly underlining an underestimation of the pandemic in Mali.
Keywords: Bamako; Mali; SARS‐CoV‐2 antibodies; associated factors; seroprevalence.