tetano
Editor, Senior Moderator
Influenza Other Respir Viruses
. 2023 Jul 12;17(7):e13172.
doi: 10.1111/irv.13172. eCollection 2023 Jul. The impact of pre-existing influenza antibodies and inflammatory status on the influenza vaccine responses in older adults
Min Kang[SUP] 1 2 [/SUP], Fangmei Lin[SUP] 3 4 [/SUP], Zhanpeng Jiang[SUP] 3 4 [/SUP], Xiaohua Tan[SUP] 2 [/SUP], Xia Lin[SUP] 3 4 [/SUP], Zaolan Liang[SUP] 3 4 5 [/SUP], Cheng Xiao[SUP] 3 4 5 [/SUP], Yonghe Xia[SUP] 6 [/SUP], Wenda Guan[SUP] 4 7 [/SUP], Zifeng Yang[SUP] 4 7 [/SUP], Guangchuang Yu[SUP] 8 [/SUP], Mark Zanin[SUP] 9 10 [/SUP], Shixing Tang[SUP] 1 [/SUP], Sook-San Wong[SUP] 5 9 [/SUP]
Affiliations
Age-associated immune changes and pre-existing influenza immunity are hypothesized to reduce influenza vaccine effectiveness in older adults, although the contribution of each factor is unknown. Here, we constructed influenza-specific IgG landscapes and determined baseline concentrations of cytokines typically associated with chronic inflammation in older adults (TNF-α, IL-10, IL-6, and IFN-γ) in 30 high and 29 low influenza vaccine responders (HR and LR, respectively). In a background of high H3 antibody titers, vaccine-specific H3, but not H1, antibody titers were boosted in LRs to titers comparable to HRs. Pre-vaccination concentrations of IL-10 were higher in LRs compared with HRs and inversely correlated with titers of pre-existing influenza antibodies. Baseline TNF-α concentrations were positively correlated with fold-increases in antibody titers in HRs. Our findings indicate that baseline inflammatory status is an important determinant for generating post-vaccination hemagglutinin-inhibition antibodies in older adults, and IgG responses can be boosted in the context of high pre-existing immunity.
Keywords: antibodies; cytokines; influenza; older adults; vaccines.
. 2023 Jul 12;17(7):e13172.
doi: 10.1111/irv.13172. eCollection 2023 Jul. The impact of pre-existing influenza antibodies and inflammatory status on the influenza vaccine responses in older adults
Min Kang[SUP] 1 2 [/SUP], Fangmei Lin[SUP] 3 4 [/SUP], Zhanpeng Jiang[SUP] 3 4 [/SUP], Xiaohua Tan[SUP] 2 [/SUP], Xia Lin[SUP] 3 4 [/SUP], Zaolan Liang[SUP] 3 4 5 [/SUP], Cheng Xiao[SUP] 3 4 5 [/SUP], Yonghe Xia[SUP] 6 [/SUP], Wenda Guan[SUP] 4 7 [/SUP], Zifeng Yang[SUP] 4 7 [/SUP], Guangchuang Yu[SUP] 8 [/SUP], Mark Zanin[SUP] 9 10 [/SUP], Shixing Tang[SUP] 1 [/SUP], Sook-San Wong[SUP] 5 9 [/SUP]
Affiliations
- PMID: 37457646
- PMCID: PMC10339007
- DOI: 10.1111/irv.13172
Age-associated immune changes and pre-existing influenza immunity are hypothesized to reduce influenza vaccine effectiveness in older adults, although the contribution of each factor is unknown. Here, we constructed influenza-specific IgG landscapes and determined baseline concentrations of cytokines typically associated with chronic inflammation in older adults (TNF-α, IL-10, IL-6, and IFN-γ) in 30 high and 29 low influenza vaccine responders (HR and LR, respectively). In a background of high H3 antibody titers, vaccine-specific H3, but not H1, antibody titers were boosted in LRs to titers comparable to HRs. Pre-vaccination concentrations of IL-10 were higher in LRs compared with HRs and inversely correlated with titers of pre-existing influenza antibodies. Baseline TNF-α concentrations were positively correlated with fold-increases in antibody titers in HRs. Our findings indicate that baseline inflammatory status is an important determinant for generating post-vaccination hemagglutinin-inhibition antibodies in older adults, and IgG responses can be boosted in the context of high pre-existing immunity.
Keywords: antibodies; cytokines; influenza; older adults; vaccines.