tetano
Editor, Senior Moderator
Influenza Other Respir Viruses
. 2023 Oct 1;17(10):e13190.
doi: 10.1111/irv.13190. eCollection 2023 Oct. Two-year trajectories of COVID-19 symptoms and their association with illness perception: A prospective cohort study in Amsterdam, the Netherlands
Elke Wynberg[SUP] 1 2 [/SUP], Anouk Verveen[SUP] 3 [/SUP], Hugo D G van Willigen[SUP] 2 [/SUP], Pythia Nieuwkerk[SUP] 3 [/SUP], Udi Davidovich[SUP] 1 3 [/SUP], Anja Lok[SUP] 4 [/SUP], Menno D de Jong[SUP] 2 [/SUP], Godelieve J de Bree[SUP] 5 [/SUP], Tjalling Leenstra[SUP] 6 [/SUP], Hans Knoop[SUP] 3 [/SUP], Maria Prins[SUP] 1 5 [/SUP], Anders Boyd[SUP] 1 7 [/SUP]; RECoVERED Study Group
Collaborators, Affiliations
Background: We used data from a prospective cohort to explore 2-year trajectories of 'long COVID' (persistent symptoms after SARS-CoV-2 infection) and their association with illness perception.
Methods: RECoVERED participants (adults; prospectively enrolled following laboratory-confirmed SARS-CoV-2 infection, May 2020-June 2021) completed symptom questionnaires at months 2-12, 18 and 24, and the Brief Illness Perception Questionnaire (B-IPQ) at months 1, 6 and 12. Using group-based trajectory models (GBTM), we modelled symptoms (mean total numbers and proportion with four specific complaints), including age, sex, BMI and timing of infection as covariates. In a multivariable linear mixed-effects model, we assessed the association between symptom trajectories and repeated B-IPQ scores.
Results: Among 292 participants (42% female; median age 51 [IQR = 36-62]), four trajectories were identified, ranging from Trajectory 4 (8.9%; 6 + symptoms) to Trajectory 1 (24.8%; no symptoms). The occurrence of fatigue and myalgia increased among 23% and 12% of participants, respectively. Individuals in Trajectory 4 experienced more negative adjusted B-IPQ scores over time than those in Trajectories 1-3.
Conclusions: We observed little fluctuation in the total number of symptoms, but individual symptoms may develop as others resolve. Reporting a greater number of symptoms was congruent with more negative illness perception over time.
Keywords: COVID‐19; illness perception; sequelae; symptoms; trajectories.
. 2023 Oct 1;17(10):e13190.
doi: 10.1111/irv.13190. eCollection 2023 Oct. Two-year trajectories of COVID-19 symptoms and their association with illness perception: A prospective cohort study in Amsterdam, the Netherlands
Elke Wynberg[SUP] 1 2 [/SUP], Anouk Verveen[SUP] 3 [/SUP], Hugo D G van Willigen[SUP] 2 [/SUP], Pythia Nieuwkerk[SUP] 3 [/SUP], Udi Davidovich[SUP] 1 3 [/SUP], Anja Lok[SUP] 4 [/SUP], Menno D de Jong[SUP] 2 [/SUP], Godelieve J de Bree[SUP] 5 [/SUP], Tjalling Leenstra[SUP] 6 [/SUP], Hans Knoop[SUP] 3 [/SUP], Maria Prins[SUP] 1 5 [/SUP], Anders Boyd[SUP] 1 7 [/SUP]; RECoVERED Study Group
Collaborators, Affiliations
- PMID: 37789876
- PMCID: PMC10542619
- DOI: 10.1111/irv.13190
Background: We used data from a prospective cohort to explore 2-year trajectories of 'long COVID' (persistent symptoms after SARS-CoV-2 infection) and their association with illness perception.
Methods: RECoVERED participants (adults; prospectively enrolled following laboratory-confirmed SARS-CoV-2 infection, May 2020-June 2021) completed symptom questionnaires at months 2-12, 18 and 24, and the Brief Illness Perception Questionnaire (B-IPQ) at months 1, 6 and 12. Using group-based trajectory models (GBTM), we modelled symptoms (mean total numbers and proportion with four specific complaints), including age, sex, BMI and timing of infection as covariates. In a multivariable linear mixed-effects model, we assessed the association between symptom trajectories and repeated B-IPQ scores.
Results: Among 292 participants (42% female; median age 51 [IQR = 36-62]), four trajectories were identified, ranging from Trajectory 4 (8.9%; 6 + symptoms) to Trajectory 1 (24.8%; no symptoms). The occurrence of fatigue and myalgia increased among 23% and 12% of participants, respectively. Individuals in Trajectory 4 experienced more negative adjusted B-IPQ scores over time than those in Trajectories 1-3.
Conclusions: We observed little fluctuation in the total number of symptoms, but individual symptoms may develop as others resolve. Reporting a greater number of symptoms was congruent with more negative illness perception over time.
Keywords: COVID‐19; illness perception; sequelae; symptoms; trajectories.