tetano
Editor, Senior Moderator
J Clin Invest. 2018 Jan 8. pii: 96957. doi: 10.1172/JCI96957. [Epub ahead of print]
[h=1]Influenza-specific lung-resident memory T cells are proliferative and polyfunctional and maintain diverse TCR profiles.[/h] Pizzolla A[SUP]1[/SUP], Nguyen TH[SUP]1[/SUP], Sant S[SUP]1[/SUP], Jaffar J[SUP]2,[/SUP][SUP]3[/SUP], Loudovaris T[SUP]4[/SUP], Mannering SI[SUP]4[/SUP], Thomas PG[SUP]5[/SUP], Westall GP[SUP]2,[/SUP][SUP]3[/SUP], Kedzierska K[SUP]1[/SUP], Wakim LM[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] The human lung harbors a large population of resident memory T cells (Trm cells). These cells are perfectly positioned to mediate rapid protection against respiratory pathogens such as influenza virus, a highly contagious respiratory pathogen that continues to be a major public health burden. Animal models show that influenza-specific lung CD8+ Trm cells are indispensable for crossprotection against pulmonary infection with different influenza virus strains. However, it is not known whether influenza-specific CD8+ Trm cells present within the human lung have the same critical role in modulating the course of the disease. Here, we showed that human lung contains a population of CD8+ Trm cells that are highly proliferative and have polyfunctional progeny. We observed that different influenza virus-specific CD8+ T cell specificities differentiated into Trm cells with varying efficiencies and that the size of the influenza-specific CD8+ T cell population persisting in the lung directly correlated with the efficiency of differentiation into Trm cells. To our knowledge, we provide the first ex vivo dissection of paired T cell receptor (TCR) repertoires of human influenza-specific CD8+ Trm cells. Our data reveal diverse TCR profiles within the human lung Trm cells and a high degree of clonal sharing with other CD8+ T cell populations, a feature important for effective T cell function and protection against the generation of viral-escape mutants.
[h=4]KEYWORDS:[/h] Adaptive immunity; Immunology; Infectious disease; Influenza; T cells
PMID: 29309047 DOI: 10.1172/JCI96957
Free full text
[h=1]Influenza-specific lung-resident memory T cells are proliferative and polyfunctional and maintain diverse TCR profiles.[/h] Pizzolla A[SUP]1[/SUP], Nguyen TH[SUP]1[/SUP], Sant S[SUP]1[/SUP], Jaffar J[SUP]2,[/SUP][SUP]3[/SUP], Loudovaris T[SUP]4[/SUP], Mannering SI[SUP]4[/SUP], Thomas PG[SUP]5[/SUP], Westall GP[SUP]2,[/SUP][SUP]3[/SUP], Kedzierska K[SUP]1[/SUP], Wakim LM[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] The human lung harbors a large population of resident memory T cells (Trm cells). These cells are perfectly positioned to mediate rapid protection against respiratory pathogens such as influenza virus, a highly contagious respiratory pathogen that continues to be a major public health burden. Animal models show that influenza-specific lung CD8+ Trm cells are indispensable for crossprotection against pulmonary infection with different influenza virus strains. However, it is not known whether influenza-specific CD8+ Trm cells present within the human lung have the same critical role in modulating the course of the disease. Here, we showed that human lung contains a population of CD8+ Trm cells that are highly proliferative and have polyfunctional progeny. We observed that different influenza virus-specific CD8+ T cell specificities differentiated into Trm cells with varying efficiencies and that the size of the influenza-specific CD8+ T cell population persisting in the lung directly correlated with the efficiency of differentiation into Trm cells. To our knowledge, we provide the first ex vivo dissection of paired T cell receptor (TCR) repertoires of human influenza-specific CD8+ Trm cells. Our data reveal diverse TCR profiles within the human lung Trm cells and a high degree of clonal sharing with other CD8+ T cell populations, a feature important for effective T cell function and protection against the generation of viral-escape mutants.
[h=4]KEYWORDS:[/h] Adaptive immunity; Immunology; Infectious disease; Influenza; T cells
PMID: 29309047 DOI: 10.1172/JCI96957
Free full text