tetano
Editor, Senior Moderator
J Microbiol Immunol Infect. 2017 Sep 6. pii: S1684-1182(17)30197-4. doi: 10.1016/j.jmii.2017.08.014. [Epub ahead of print]
[h=1]Influenza vaccination and risk of respiratory failure in patients with chronic obstructive pulmonary disease: A nationwide population-based case-cohort study.[/h] Huang HH[SUP]1[/SUP], Chen SJ[SUP]2[/SUP], Chao TF[SUP]3[/SUP], Liu CJ[SUP]4[/SUP], Chen TJ[SUP]5[/SUP], Chou P[SUP]6[/SUP], Wang FD[SUP]7[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease which causes a considerable disease burden. Patients with COPD are at a higher risk for influenza infection and influenza vaccination are recommended at this high risk patient group. In the current study, we aimed to evaluate the association between influenza vaccination and the risk of respiratory failure (RF) in COPD patients.
[h=4]METHODS:[/h] From 2001 to 2005, patients with newly diagnosed COPD were identified from the NHIRD, and were followed until 2010. We explored the influenza vaccination rate among this COPD cohort. Furthermore, patients who experienced RF were defined as case group, whereas the others were defined as control group. Baseline characteristic were compared and association between influenza vaccination and RF were evaluated.
[h=4]RESULTS:[/h] The rate of influenza vaccination was significantly higher in patients age ≥65 years than those age <65 years (54.8% vs. 4%, p < 0.001). The vaccine cohort had more comorbidities, more health care utilization and more frequent acute exacerbations as compared with nonvaccine cohort. In multivariable logistic regression, influenza vaccination was associated with a reduced risk of respiratory failure (adjusted odds ratio [aOR] 0.87, 95% confidence interval [CI] 0.79-0.96). In subgroup analysis, we found that the association was insignificant in patients age <65 years, patients with relatively unstable disease status and patient did not receive influenza vaccination annually.
[h=4]CONCLUSIONS:[/h] Influenza vaccination was associated with a decreased risk of RF in patients with COPD. Recommendation of annual influenza vaccination should be made when managing this high-risk patient group.
Copyright ? 2017. Published by Elsevier B.V.
[h=4]KEYWORDS:[/h] Chronic obstructive pulmonary disease; Influenza; Respiratory failure; Taiwan National Health Insurance Research Database; Vaccine
PMID: 28927683 DOI: 10.1016/j.jmii.2017.08.014
[h=1]Influenza vaccination and risk of respiratory failure in patients with chronic obstructive pulmonary disease: A nationwide population-based case-cohort study.[/h] Huang HH[SUP]1[/SUP], Chen SJ[SUP]2[/SUP], Chao TF[SUP]3[/SUP], Liu CJ[SUP]4[/SUP], Chen TJ[SUP]5[/SUP], Chou P[SUP]6[/SUP], Wang FD[SUP]7[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease which causes a considerable disease burden. Patients with COPD are at a higher risk for influenza infection and influenza vaccination are recommended at this high risk patient group. In the current study, we aimed to evaluate the association between influenza vaccination and the risk of respiratory failure (RF) in COPD patients.
[h=4]METHODS:[/h] From 2001 to 2005, patients with newly diagnosed COPD were identified from the NHIRD, and were followed until 2010. We explored the influenza vaccination rate among this COPD cohort. Furthermore, patients who experienced RF were defined as case group, whereas the others were defined as control group. Baseline characteristic were compared and association between influenza vaccination and RF were evaluated.
[h=4]RESULTS:[/h] The rate of influenza vaccination was significantly higher in patients age ≥65 years than those age <65 years (54.8% vs. 4%, p < 0.001). The vaccine cohort had more comorbidities, more health care utilization and more frequent acute exacerbations as compared with nonvaccine cohort. In multivariable logistic regression, influenza vaccination was associated with a reduced risk of respiratory failure (adjusted odds ratio [aOR] 0.87, 95% confidence interval [CI] 0.79-0.96). In subgroup analysis, we found that the association was insignificant in patients age <65 years, patients with relatively unstable disease status and patient did not receive influenza vaccination annually.
[h=4]CONCLUSIONS:[/h] Influenza vaccination was associated with a decreased risk of RF in patients with COPD. Recommendation of annual influenza vaccination should be made when managing this high-risk patient group.
Copyright ? 2017. Published by Elsevier B.V.
[h=4]KEYWORDS:[/h] Chronic obstructive pulmonary disease; Influenza; Respiratory failure; Taiwan National Health Insurance Research Database; Vaccine
PMID: 28927683 DOI: 10.1016/j.jmii.2017.08.014