tetano
Editor, Senior Moderator
Vaccine. 2017 Nov 8. pii: S0264-410X(17)31525-6. doi: 10.1016/j.vaccine.2017.10.096. [Epub ahead of print]
[h=1]Influenza vaccination in preventing outbreaks in schools: A long-term ecological overview.[/h] Pan Y[SUP]1[/SUP], Wang Q[SUP]2[/SUP], Yang P[SUP]3[/SUP], Zhang L[SUP]4[/SUP], Wu S[SUP]4[/SUP], Zhang Y[SUP]4[/SUP], Sun Y[SUP]4[/SUP], Duan W[SUP]4[/SUP], Ma C[SUP]4[/SUP], Zhang M[SUP]4[/SUP], Zhang X[SUP]4[/SUP], MacIntyre CR[SUP]5[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Influenza vaccination is the most effective way to reduce the incidence of influenza infections. However, the role of influenza vaccination, such as school-based influenza vaccination, in preventing the influenza outbreaks in schools remains unclear now. In this study, a total of 286 school febrile outbreaks involving 6863 cases in the Beijing area from September 1, 2006 to March 31, 2017 were analyzed. We also tested 294 circulating strains isolated in Beijing during the same period and compared with that of vaccine strains identified every influenza season. The virological match/mismatch between vaccine strains and circulating strains, and the coverage of vaccination in schools were analyzed against outbreaks during the 11 years. It showed that over 80% school febrile outbreaks were caused by influenza A/B virus, the most frequent being A(H3N2) virus (53.25%), followed by A(H1N1)pdm09 virus (25.11%) and B virus (21.64%). More importantly, low vaccine coverage (in 2006-2007 influenza season) and vaccine mismatch (in 2014-2015 and 2015-2016 influenza season) were associated with an increased number of influenza school outbreaks. High vaccination coverage with a matched vaccine can significantly reduce influenza outbreaks in schools (OR: 0.111, p < .001). We have shown the effectiveness of school-based influenza vaccination in preventing outbreaks using trivalent inactivated influenza vaccine in schools. Thus the school-based vaccine policy should be paid more attention in China and other countries worldwide.
Copyright ? 2017 Elsevier Ltd. All rights reserved.
[h=4]KEYWORDS:[/h] Hemagglutination; Influenza; Outbreak; Schools; Vaccine
PMID: 29128383 DOI: 10.1016/j.vaccine.2017.10.096
[h=1]Influenza vaccination in preventing outbreaks in schools: A long-term ecological overview.[/h] Pan Y[SUP]1[/SUP], Wang Q[SUP]2[/SUP], Yang P[SUP]3[/SUP], Zhang L[SUP]4[/SUP], Wu S[SUP]4[/SUP], Zhang Y[SUP]4[/SUP], Sun Y[SUP]4[/SUP], Duan W[SUP]4[/SUP], Ma C[SUP]4[/SUP], Zhang M[SUP]4[/SUP], Zhang X[SUP]4[/SUP], MacIntyre CR[SUP]5[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Influenza vaccination is the most effective way to reduce the incidence of influenza infections. However, the role of influenza vaccination, such as school-based influenza vaccination, in preventing the influenza outbreaks in schools remains unclear now. In this study, a total of 286 school febrile outbreaks involving 6863 cases in the Beijing area from September 1, 2006 to March 31, 2017 were analyzed. We also tested 294 circulating strains isolated in Beijing during the same period and compared with that of vaccine strains identified every influenza season. The virological match/mismatch between vaccine strains and circulating strains, and the coverage of vaccination in schools were analyzed against outbreaks during the 11 years. It showed that over 80% school febrile outbreaks were caused by influenza A/B virus, the most frequent being A(H3N2) virus (53.25%), followed by A(H1N1)pdm09 virus (25.11%) and B virus (21.64%). More importantly, low vaccine coverage (in 2006-2007 influenza season) and vaccine mismatch (in 2014-2015 and 2015-2016 influenza season) were associated with an increased number of influenza school outbreaks. High vaccination coverage with a matched vaccine can significantly reduce influenza outbreaks in schools (OR: 0.111, p < .001). We have shown the effectiveness of school-based influenza vaccination in preventing outbreaks using trivalent inactivated influenza vaccine in schools. Thus the school-based vaccine policy should be paid more attention in China and other countries worldwide.
Copyright ? 2017 Elsevier Ltd. All rights reserved.
[h=4]KEYWORDS:[/h] Hemagglutination; Influenza; Outbreak; Schools; Vaccine
PMID: 29128383 DOI: 10.1016/j.vaccine.2017.10.096