tetano
Editor, Senior Moderator
Vaccine. 2017 Apr 3. pii: S0264-410X(17)30390-0. doi: 10.1016/j.vaccine.2017.03.063. [Epub ahead of print]
[h=1]Influenza vaccination responses: Evaluating impact of repeat vaccination among health care workers.[/h] Leung VK[SUP]1[/SUP], Carolan LA[SUP]2[/SUP], Worth LJ[SUP]3[/SUP], Harper SA[SUP]3[/SUP], Peck H[SUP]2[/SUP], Tilmanis D[SUP]2[/SUP], Laurie KL[SUP]2[/SUP], Slavin MA[SUP]3[/SUP], Sullivan SG[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]OBJECTIVE:[/h] To compare the antibody response to influenza between health care workers (HCWs) who have received multiple vaccinations (high vaccination group) and those who have received fewer vaccinations (low vaccination group).
[h=4]DESIGN:[/h] Prospective serosurvey.
[h=4]SETTING:[/h] Tertiary referral hospital.
[h=4]PARTICIPANTS:[/h] Healthcare workers.
[h=4]METHODS:[/h] Healthcare workers were vaccinated with the 2015 southern hemisphere trivalent influenza vaccine. Influenza antibody titres were measured pre-vaccination, 21-28days post-vaccination and 6months post-vaccination. Antibody titres were measured using the haemagglutination inhibition assay. Levels of seropositivity and estimated geometric mean titres were calculated.
[h=4]RESULTS:[/h] Of the 202 HCWs enrolled, 182 completed the study (143 high vaccination and 39 low vaccination). Both vaccination groups demonstrated increases in post-vaccination geometric mean titres, with greater gains in the low vaccination group. Seropositivity remained high in both high and low vaccination groups post-vaccination. The highest fold rise was observed among HCWs in the low vaccination group against the H3N2 component of the vaccine.
[h=4]CONCLUSIONS:[/h] Both high and low vaccination groups in our study demonstrated protective antibody titres post-vaccination. The findings from the current study are suggestive of decreased serological response among highly vaccinated HCWs. More studies with larger sample sizes and a greater number of people in the vaccine-na?ve and once-vaccinated groups are required to confirm or refute these findings before making any policy changes.
Copyright ? 2017 Elsevier Ltd. All rights reserved.
[h=4]KEYWORDS:[/h] Antibody; Focus reduction assay; Healthcare worker; Hemagglutination inhibition assay; Immunogenicity; Influenza vaccine
PMID: 28385605 DOI: 10.1016/j.vaccine.2017.03.063
[h=1]Influenza vaccination responses: Evaluating impact of repeat vaccination among health care workers.[/h] Leung VK[SUP]1[/SUP], Carolan LA[SUP]2[/SUP], Worth LJ[SUP]3[/SUP], Harper SA[SUP]3[/SUP], Peck H[SUP]2[/SUP], Tilmanis D[SUP]2[/SUP], Laurie KL[SUP]2[/SUP], Slavin MA[SUP]3[/SUP], Sullivan SG[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]OBJECTIVE:[/h] To compare the antibody response to influenza between health care workers (HCWs) who have received multiple vaccinations (high vaccination group) and those who have received fewer vaccinations (low vaccination group).
[h=4]DESIGN:[/h] Prospective serosurvey.
[h=4]SETTING:[/h] Tertiary referral hospital.
[h=4]PARTICIPANTS:[/h] Healthcare workers.
[h=4]METHODS:[/h] Healthcare workers were vaccinated with the 2015 southern hemisphere trivalent influenza vaccine. Influenza antibody titres were measured pre-vaccination, 21-28days post-vaccination and 6months post-vaccination. Antibody titres were measured using the haemagglutination inhibition assay. Levels of seropositivity and estimated geometric mean titres were calculated.
[h=4]RESULTS:[/h] Of the 202 HCWs enrolled, 182 completed the study (143 high vaccination and 39 low vaccination). Both vaccination groups demonstrated increases in post-vaccination geometric mean titres, with greater gains in the low vaccination group. Seropositivity remained high in both high and low vaccination groups post-vaccination. The highest fold rise was observed among HCWs in the low vaccination group against the H3N2 component of the vaccine.
[h=4]CONCLUSIONS:[/h] Both high and low vaccination groups in our study demonstrated protective antibody titres post-vaccination. The findings from the current study are suggestive of decreased serological response among highly vaccinated HCWs. More studies with larger sample sizes and a greater number of people in the vaccine-na?ve and once-vaccinated groups are required to confirm or refute these findings before making any policy changes.
Copyright ? 2017 Elsevier Ltd. All rights reserved.
[h=4]KEYWORDS:[/h] Antibody; Focus reduction assay; Healthcare worker; Hemagglutination inhibition assay; Immunogenicity; Influenza vaccine
PMID: 28385605 DOI: 10.1016/j.vaccine.2017.03.063