tetano
Editor, Senior Moderator
Int J Clin Pract. 2019 May 9:e13361. doi: 10.1111/ijcp.13361. [Epub ahead of print]
[h=1]Influenza Vaccine ? A viable Option to Protect Pregnant women and Infant from Seasonal Flu: a retrospective Hospital based study in India.[/h] Singh M[SUP]1[/SUP], Tanvir T[SUP]2[/SUP], Nagoji D[SUP]3[/SUP], Madan A[SUP]2[/SUP], Gattem S[SUP]2[/SUP], Singh H[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Influenza is a highly contagious disease with global annual outbreaks of 3-5 million severe cases and 0.25 to 0.5 million deaths. The risk is greater in pregnant women that results in high morbidity and mortality.
[h=4]OBJECTIVE:[/h] The objective of this study was to see the efficacy of influenza vaccine on pregnant women and their newborn upto six months.
[h=4]METHOD:[/h] This was a retrospective study (January 2016-March 2018). Records of 346 pregnant women were included in this study (vaccinated: 288; unvaccinated: 58). Women and infants were categorized into Category A, B or C according to the guidelines issued by the Ministry of Health and Family Welfare, India on influenza.
[h=4]RESULTS:[/h] The groups were comparable with respect to baseline characteristics. Greater number of women received influenza vaccine during the 1[SUP]st[/SUP] trimester (n=117). During the gestation period, majority of the women in the vaccinated group were symptom free compared to the unvaccinated (92% vs 70.7%). Also, none of the vaccinated women were categorized into category C compared to one who was laboratory tested positive for influenza in the unvaccinated group. Similar results were seen postpartum and more number of infants remained symptoms free in the vaccinated group compared with unvaccinated (69.3% vs 25.9%). More number of infants were born pre-term in the unvaccinated group compared to vaccinated (15.5% vs 8.6%).
[h=4]CONCLUSIONS:[/h] Immunization with influenza vaccine in any trimester during pregnancy was found to protect the mother and infants upto 6 months of age against seasonal influenza without significant maternal adverse effects. In order to improve vaccination rates, there must be a national vaccination policy and incorporation of maternal immunisation in standard antenatal care. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
[h=4]KEYWORDS:[/h] Infant; Influenza; Pregnant; Vaccine
PMID: 31074182 DOI: 10.1111/ijcp.13361
[h=1]Influenza Vaccine ? A viable Option to Protect Pregnant women and Infant from Seasonal Flu: a retrospective Hospital based study in India.[/h] Singh M[SUP]1[/SUP], Tanvir T[SUP]2[/SUP], Nagoji D[SUP]3[/SUP], Madan A[SUP]2[/SUP], Gattem S[SUP]2[/SUP], Singh H[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Influenza is a highly contagious disease with global annual outbreaks of 3-5 million severe cases and 0.25 to 0.5 million deaths. The risk is greater in pregnant women that results in high morbidity and mortality.
[h=4]OBJECTIVE:[/h] The objective of this study was to see the efficacy of influenza vaccine on pregnant women and their newborn upto six months.
[h=4]METHOD:[/h] This was a retrospective study (January 2016-March 2018). Records of 346 pregnant women were included in this study (vaccinated: 288; unvaccinated: 58). Women and infants were categorized into Category A, B or C according to the guidelines issued by the Ministry of Health and Family Welfare, India on influenza.
[h=4]RESULTS:[/h] The groups were comparable with respect to baseline characteristics. Greater number of women received influenza vaccine during the 1[SUP]st[/SUP] trimester (n=117). During the gestation period, majority of the women in the vaccinated group were symptom free compared to the unvaccinated (92% vs 70.7%). Also, none of the vaccinated women were categorized into category C compared to one who was laboratory tested positive for influenza in the unvaccinated group. Similar results were seen postpartum and more number of infants remained symptoms free in the vaccinated group compared with unvaccinated (69.3% vs 25.9%). More number of infants were born pre-term in the unvaccinated group compared to vaccinated (15.5% vs 8.6%).
[h=4]CONCLUSIONS:[/h] Immunization with influenza vaccine in any trimester during pregnancy was found to protect the mother and infants upto 6 months of age against seasonal influenza without significant maternal adverse effects. In order to improve vaccination rates, there must be a national vaccination policy and incorporation of maternal immunisation in standard antenatal care. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
[h=4]KEYWORDS:[/h] Infant; Influenza; Pregnant; Vaccine
PMID: 31074182 DOI: 10.1111/ijcp.13361