tetano
Editor, Senior Moderator
Vaccine. 2015 Oct 31. pii: S0264-410X(15)01431-0. doi: 10.1016/j.vaccine.2015.10.016. [Epub ahead of print]
[h=1]Influenza vaccine effectiveness against hospitalisation with influenza in adults in Australia in 2014.[/h] Cheng AC[SUP]1[/SUP], Kotsimbos T[SUP]2[/SUP], Kelly PM[SUP]3[/SUP]; FluCAN Investigators.
[h=3]Author information[/h]
[h=3]Abstract[/h] We provide estimates of the influenza vaccine protection against hospitalisation with laboratory-confirmed influenza in the 2014 Australian season where the A/H1N1/pdm09 strain predominated. This was performed using a case-test negative study design as part of a national sentinel surveillance system in Australia. Vaccine effectiveness was estimated as (1-OR)?100% where the odds ratio of vaccination in cases vs test negative participants was estimated from a conditional logistic regression. Between April and November, 1692 adult patients were admitted with laboratory-confirmed influenza. Vaccine effectiveness was estimated from 1283 patients with influenza and 1116 test negative patients where vaccination status was ascertained. Vaccination was associated with a reduction in the risk of hospitalisation with influenza of 51.5% (95% CI: 41.6%, 59.7%) in all patients, and a reduction of 50.7% (95% CI: 40.1%, 59.3%) in the target population for vaccination. We estimate that the influenza vaccine was moderately protective against hospitalisation with laboratory-confirmed influenza during the 2014 influenza season in Australia.
Copyright ? 2015 Elsevier Ltd. All rights reserved.
[h=4]KEYWORDS:[/h] Hospitalisation; Influenza vaccination; Test negative design; Vaccine effectiveness
PMID: 26529066 [PubMed - as supplied by publisher]
[h=1]Influenza vaccine effectiveness against hospitalisation with influenza in adults in Australia in 2014.[/h] Cheng AC[SUP]1[/SUP], Kotsimbos T[SUP]2[/SUP], Kelly PM[SUP]3[/SUP]; FluCAN Investigators.
[h=3]Author information[/h]
[h=3]Abstract[/h] We provide estimates of the influenza vaccine protection against hospitalisation with laboratory-confirmed influenza in the 2014 Australian season where the A/H1N1/pdm09 strain predominated. This was performed using a case-test negative study design as part of a national sentinel surveillance system in Australia. Vaccine effectiveness was estimated as (1-OR)?100% where the odds ratio of vaccination in cases vs test negative participants was estimated from a conditional logistic regression. Between April and November, 1692 adult patients were admitted with laboratory-confirmed influenza. Vaccine effectiveness was estimated from 1283 patients with influenza and 1116 test negative patients where vaccination status was ascertained. Vaccination was associated with a reduction in the risk of hospitalisation with influenza of 51.5% (95% CI: 41.6%, 59.7%) in all patients, and a reduction of 50.7% (95% CI: 40.1%, 59.3%) in the target population for vaccination. We estimate that the influenza vaccine was moderately protective against hospitalisation with laboratory-confirmed influenza during the 2014 influenza season in Australia.
Copyright ? 2015 Elsevier Ltd. All rights reserved.
[h=4]KEYWORDS:[/h] Hospitalisation; Influenza vaccination; Test negative design; Vaccine effectiveness
PMID: 26529066 [PubMed - as supplied by publisher]