tetano
Editor, Senior Moderator
Vaccine. 2014 Sep 12. pii: S0264-410X(14)01224-9. doi: 10.1016/j.vaccine.2014.08.066. [Epub ahead of print]
Influenza vaccine effectiveness estimates for Western Australia during a period of vaccine and virus strain stability, 2010 to 2012.
Levy A1, Sullivan SG2, Tempone S1, Wong KL3, Regan A4, Dowse GK4, Effler P4, Smith D1.
Author information
Abstract
During 2010-2012 the strain composition of the influenza vaccine in the Southern Hemisphere did not change, but the circulating virus type/subtype did. We pooled data for these years from the Western Australian sentinel medical practice surveillance system for influenza to estimate vaccine effectiveness (VE) by influenza virus type and subtype. A case test-negative design was used with VE estimated as (1-odds ratio)?100%. There were 2182 patients included in the analysis across the 3 years studied. The predominant subtype was A/H1pdm09 in 2010 and 2011, and A/H3 in 2012. The overall adjusted VE estimate against all influenza for 2010-2012 was 51% (95% CI: 36, 63). Estimates were highest against A/H1pdm09 at 74% (95% CI: 47, 87), followed by 56% (95% CI: 33, 71) for influenza B and lowest against A/H3 at 39% (95% CI: 13, 57). When analyses were restricted to compare influenza-positive patients with patients who tested positive for a non-influenza virus, overall adjusted VE was 59% (95% CI: 39, 72). These results suggest moderate protection against influenza by vaccination in Western Australia over the period 2010-2012, and are consistent with findings from other settings.
Copyright ? 2014. Published by Elsevier Ltd.
KEYWORDS:
Data pooling; Influenza; Influenza season; Influenza vaccine; Influenza-like illness; Vaccine effectiveness
PMID:
25223268
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25223268
Influenza vaccine effectiveness estimates for Western Australia during a period of vaccine and virus strain stability, 2010 to 2012.
Levy A1, Sullivan SG2, Tempone S1, Wong KL3, Regan A4, Dowse GK4, Effler P4, Smith D1.
Author information
Abstract
During 2010-2012 the strain composition of the influenza vaccine in the Southern Hemisphere did not change, but the circulating virus type/subtype did. We pooled data for these years from the Western Australian sentinel medical practice surveillance system for influenza to estimate vaccine effectiveness (VE) by influenza virus type and subtype. A case test-negative design was used with VE estimated as (1-odds ratio)?100%. There were 2182 patients included in the analysis across the 3 years studied. The predominant subtype was A/H1pdm09 in 2010 and 2011, and A/H3 in 2012. The overall adjusted VE estimate against all influenza for 2010-2012 was 51% (95% CI: 36, 63). Estimates were highest against A/H1pdm09 at 74% (95% CI: 47, 87), followed by 56% (95% CI: 33, 71) for influenza B and lowest against A/H3 at 39% (95% CI: 13, 57). When analyses were restricted to compare influenza-positive patients with patients who tested positive for a non-influenza virus, overall adjusted VE was 59% (95% CI: 39, 72). These results suggest moderate protection against influenza by vaccination in Western Australia over the period 2010-2012, and are consistent with findings from other settings.
Copyright ? 2014. Published by Elsevier Ltd.
KEYWORDS:
Data pooling; Influenza; Influenza season; Influenza vaccine; Influenza-like illness; Vaccine effectiveness
PMID:
25223268
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25223268