tetano
Editor, Senior Moderator
Matern Child Health J. 2019 Dec 21. doi: 10.1007/s10995-019-02844-y. [Epub ahead of print] [h=1]Influenza Vaccine Efficacy and Effectiveness in Pregnant Women: Systematic Review and Meta-analysis.[/h]
Quach THT[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3[/SUP], Mallis NA[SUP]1[/SUP], Cordero JF[SUP]4[/SUP].
[h=3]Author information[/h] 1 Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens, GA, 30602, USA. 2 Institute for Global Health, College of Public Health, University of Georgia, Athens, GA, 30602, USA. 3 Faculty of Pharmacy, Ho Chi Minh City University of Technology (HUTECH), Ho Chi Minh City, Vietnam. 4 Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens, GA, 30602, USA. jcordero@uga.edu.
[h=3]Abstract[/h] [h=4]OBJECTIVE:[/h] Pregnant women have a high risk for complications from influenza infection, but vaccination rates within this group remain low in the US and other countries. The efficacy and effectiveness of the influenza vaccine are a key determinant of vaccine uptake. This review aimed to synthesize the available evidence on the protection of both seasonal and monovalent pandemic H1N1 (pdmH1N1) vaccine against laboratory-confirmed influenza (LCI), influenza-like illness (ILI), and respiratory illness (RI).
[h=4]METHODS:[/h] A search of the literature was undertaken from Pubmed, Embase, ClinicalTrials.gov, and Cochrane Central Register of Controlled Trials up to Aug 1, 2018. Both observational studies and clinical trials were considered.
[h=4]RESULTS:[/h] Nineteen studies were identified from 11 countries. Women with pdmH1N1 vaccination had a lower risk of getting LCI (Relative risk [RR] 0.3, 95% confidence interval [CI] 0.26-0.35) and ILI (RR 0.15, 95% CI 0.06-0.36)). The pooled estimate from three randomized clinical trials (RR 0.47, 95% CI 0.31-0.71) and two case control studies (OR 0.37, 95% CI 0.23-0.61) showed that the seasonal vaccine was protective against LCI. The seasonal vaccine was not protective against ILI (RR 0.95, 95% CI 0.88-1.03). This association was similar for the outcome of RI (RR 0.81, 95% CI 0.55-1.20).
[h=4]CONCLUSION:[/h] This analysis bolsters existing evidence that influenza vaccines are effective among pregnant women. Additional public health efforts are needed to promote physician recommendations of influenza vaccination in pregnancy.
[h=4]KEYWORDS:[/h] Influenza; Meta-analysis; Pregnancy; Vaccine effectiveness; Vaccine efficacy
PMID: 31865602 DOI: 10.1007/s10995-019-02844-y
Quach THT[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3[/SUP], Mallis NA[SUP]1[/SUP], Cordero JF[SUP]4[/SUP].
[h=3]Author information[/h] 1 Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens, GA, 30602, USA. 2 Institute for Global Health, College of Public Health, University of Georgia, Athens, GA, 30602, USA. 3 Faculty of Pharmacy, Ho Chi Minh City University of Technology (HUTECH), Ho Chi Minh City, Vietnam. 4 Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens, GA, 30602, USA. jcordero@uga.edu.
[h=3]Abstract[/h] [h=4]OBJECTIVE:[/h] Pregnant women have a high risk for complications from influenza infection, but vaccination rates within this group remain low in the US and other countries. The efficacy and effectiveness of the influenza vaccine are a key determinant of vaccine uptake. This review aimed to synthesize the available evidence on the protection of both seasonal and monovalent pandemic H1N1 (pdmH1N1) vaccine against laboratory-confirmed influenza (LCI), influenza-like illness (ILI), and respiratory illness (RI).
[h=4]METHODS:[/h] A search of the literature was undertaken from Pubmed, Embase, ClinicalTrials.gov, and Cochrane Central Register of Controlled Trials up to Aug 1, 2018. Both observational studies and clinical trials were considered.
[h=4]RESULTS:[/h] Nineteen studies were identified from 11 countries. Women with pdmH1N1 vaccination had a lower risk of getting LCI (Relative risk [RR] 0.3, 95% confidence interval [CI] 0.26-0.35) and ILI (RR 0.15, 95% CI 0.06-0.36)). The pooled estimate from three randomized clinical trials (RR 0.47, 95% CI 0.31-0.71) and two case control studies (OR 0.37, 95% CI 0.23-0.61) showed that the seasonal vaccine was protective against LCI. The seasonal vaccine was not protective against ILI (RR 0.95, 95% CI 0.88-1.03). This association was similar for the outcome of RI (RR 0.81, 95% CI 0.55-1.20).
[h=4]CONCLUSION:[/h] This analysis bolsters existing evidence that influenza vaccines are effective among pregnant women. Additional public health efforts are needed to promote physician recommendations of influenza vaccination in pregnancy.
[h=4]KEYWORDS:[/h] Influenza; Meta-analysis; Pregnancy; Vaccine effectiveness; Vaccine efficacy
PMID: 31865602 DOI: 10.1007/s10995-019-02844-y