tetano
Editor, Senior Moderator
J Infect Dis. 2014 Oct 21. pii: jiu578. [Epub ahead of print]
Influenza Vaccine Prevents Medically-Attended Influenza-Associated Acute Respiratory Illness in Adults 50 Years or Older.
Chen Q1, Griffin MR2, Nian H3, Zhu Y3, Williams JV4, Edwards KM5, Talbot HK6.
Author information
Abstract
BACKGROUND:
There are few estimates of influenza vaccine effectiveness in preventing serious outcomes in older adults.
METHODS:
Adults age ≥50 years who sought medical care for acute respiratory illness were enrolled. A nose/throat swab was tested for influenza by reverse-transcriptase polymerase chain reaction. Clinical and demographic data were collected, including verification of receipt of trivalent inactivated influenza vaccination (IIV-3). Adjusted ORs were estimated by multivariable logistic regression models with L1 penalty on all covariates except vaccination status (LASSO).
RESULTS:
1189 subjects were enrolled from November - April during five influenza seasons, 2006 through 2012, excluding the 2009-2010 season. Of those enrolled, 1064 (89%) had complete influenza testing, vaccination status, and demographic data obtained. Of 114 (9.5%) influenza positive patients, 63 (55%) were vaccinated. Of 950 patients influenza negative patients, 726 (76%) were vaccinated. Over 5 influenza seasons, IIV-3 was 61.9% (95% CI: 34.2, 72.3) effective for the prevention of medically-attended laboratory-confirmed influenza illness in adults ≥50 years and 55.2% (95% CI: 0.2, 77.3) effective in adults ≥65 years. When considering only hospitalizations, overall vaccine effectiveness was 58.4% in adults ≥50 years (95%CI: 37.0, 75.6).
CONCLUSIONS:
Influenza vaccine was moderately effective in preventing influenza-associated medical care visits in older adults.
? The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
PMID:
25336724
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25336724
Influenza Vaccine Prevents Medically-Attended Influenza-Associated Acute Respiratory Illness in Adults 50 Years or Older.
Chen Q1, Griffin MR2, Nian H3, Zhu Y3, Williams JV4, Edwards KM5, Talbot HK6.
Author information
Abstract
BACKGROUND:
There are few estimates of influenza vaccine effectiveness in preventing serious outcomes in older adults.
METHODS:
Adults age ≥50 years who sought medical care for acute respiratory illness were enrolled. A nose/throat swab was tested for influenza by reverse-transcriptase polymerase chain reaction. Clinical and demographic data were collected, including verification of receipt of trivalent inactivated influenza vaccination (IIV-3). Adjusted ORs were estimated by multivariable logistic regression models with L1 penalty on all covariates except vaccination status (LASSO).
RESULTS:
1189 subjects were enrolled from November - April during five influenza seasons, 2006 through 2012, excluding the 2009-2010 season. Of those enrolled, 1064 (89%) had complete influenza testing, vaccination status, and demographic data obtained. Of 114 (9.5%) influenza positive patients, 63 (55%) were vaccinated. Of 950 patients influenza negative patients, 726 (76%) were vaccinated. Over 5 influenza seasons, IIV-3 was 61.9% (95% CI: 34.2, 72.3) effective for the prevention of medically-attended laboratory-confirmed influenza illness in adults ≥50 years and 55.2% (95% CI: 0.2, 77.3) effective in adults ≥65 years. When considering only hospitalizations, overall vaccine effectiveness was 58.4% in adults ≥50 years (95%CI: 37.0, 75.6).
CONCLUSIONS:
Influenza vaccine was moderately effective in preventing influenza-associated medical care visits in older adults.
? The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
PMID:
25336724
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25336724