tetano
Editor, Senior Moderator
Antimicrob Agents Chemother. 2014 Dec 29. pii: AAC.04263-14. [Epub ahead of print]
[h=1]Influenza Viral Load and Peramivir Kinetics after Single Administration and Proposal of Regimens for Peramivir Administration against Resistant Variants.[/h] Sato M[SUP]1[/SUP], Ito M[SUP]2[/SUP], Suzuki S[SUP]3[/SUP], Sakuma H[SUP]4[/SUP], Takeyama A[SUP]2[/SUP], Oda S[SUP]5[/SUP], Watanabe M[SUP]6[/SUP], Hashimoto K[SUP]7[/SUP], Miyazaki K[SUP]7[/SUP], Kawasaki Y[SUP]7[/SUP], Hosoya M[SUP]7[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] We estimated the efficacy of the current single administration of peramivir on the basis of peramivir pharmacokinetics in the upper respiratory tract (URT) and determined the predictive peramivir concentration-time curve to assess its efficacy against viruses with decreased susceptibility to neuraminidase inhibitors. Serum, nasal swab, or aspiration samples were collected from 28 patients treated with 10 mg/kg peramivir. Sequential influenza viral RNA load and susceptibility after peramivir administration were measured using a quantitative real-time reverse transcription-polymerase chain reaction and neuraminidase inhibition assay. The peramivir concentration in serum and URT after a single administration at 10 mg/kg was measured and the predictive blood and URT peramivir concentration-time curve was determined to assess various administration regimens against resistant variants. The serum peramivir concentration decreased to <0.1% of C[SUB]max[/SUB] at 24 h after administration. Rapid elimination of peramivir from URT by 48 h after administration may contribute to an increase in the influenza A viral load after day 3 but not to a decrease in the influenza B viral load, despite the absence of decrease in susceptibility to peramivir. A longer maintenance of high level of peramivir in URT is expected by divided administration rather than once daily administration. When no clinical improvement is observed in patients with normal-susceptibility influenza A and B, peramivir readministration should be considered. In severe cases caused by resistant variants, better inhibitory effectiveness and less frequent adverse events is expected by divided administration rather than the once daily administration with an increased dosage.
Copyright ? 2014, American Society for Microbiology. All Rights Reserved.
PMID: 25547357 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25547357
[h=1]Influenza Viral Load and Peramivir Kinetics after Single Administration and Proposal of Regimens for Peramivir Administration against Resistant Variants.[/h] Sato M[SUP]1[/SUP], Ito M[SUP]2[/SUP], Suzuki S[SUP]3[/SUP], Sakuma H[SUP]4[/SUP], Takeyama A[SUP]2[/SUP], Oda S[SUP]5[/SUP], Watanabe M[SUP]6[/SUP], Hashimoto K[SUP]7[/SUP], Miyazaki K[SUP]7[/SUP], Kawasaki Y[SUP]7[/SUP], Hosoya M[SUP]7[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] We estimated the efficacy of the current single administration of peramivir on the basis of peramivir pharmacokinetics in the upper respiratory tract (URT) and determined the predictive peramivir concentration-time curve to assess its efficacy against viruses with decreased susceptibility to neuraminidase inhibitors. Serum, nasal swab, or aspiration samples were collected from 28 patients treated with 10 mg/kg peramivir. Sequential influenza viral RNA load and susceptibility after peramivir administration were measured using a quantitative real-time reverse transcription-polymerase chain reaction and neuraminidase inhibition assay. The peramivir concentration in serum and URT after a single administration at 10 mg/kg was measured and the predictive blood and URT peramivir concentration-time curve was determined to assess various administration regimens against resistant variants. The serum peramivir concentration decreased to <0.1% of C[SUB]max[/SUB] at 24 h after administration. Rapid elimination of peramivir from URT by 48 h after administration may contribute to an increase in the influenza A viral load after day 3 but not to a decrease in the influenza B viral load, despite the absence of decrease in susceptibility to peramivir. A longer maintenance of high level of peramivir in URT is expected by divided administration rather than once daily administration. When no clinical improvement is observed in patients with normal-susceptibility influenza A and B, peramivir readministration should be considered. In severe cases caused by resistant variants, better inhibitory effectiveness and less frequent adverse events is expected by divided administration rather than the once daily administration with an increased dosage.
Copyright ? 2014, American Society for Microbiology. All Rights Reserved.
PMID: 25547357 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25547357