tetano
Editor, Senior Moderator
Virus Res. 2015 Feb 9. pii: S0168-1702(15)00056-8. doi: 10.1016/j.virusres.2015.02.003. [Epub ahead of print]
[h=1]Influenza virus activation of the interferon system.[/h] Killip MJ[SUP]1[/SUP], Fodor E[SUP]2[/SUP], Randall RE[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] The host interferon (IFN) response represents one of the first barriers that influenza viruses must surmount in order to establish an infection. Many advances have been made in recent years in the understanding of the interactions between influenza viruses and the interferon system. In this review, we summarise recent work regarding activation of the type I IFN response by influenza viruses, including attempts to identify the viral RNA responsible for IFN induction, the stage of the virus life cycle at which it is generated and the role of defective viruses in this process.
Copyright ? 2015. Published by Elsevier B.V.
[h=4]KEYWORDS:[/h] Influenza viruses; RIG-I; innate immunity; interferon
PMID: 25678267 [PubMed - as supplied by publisher]
[h=1]Influenza virus activation of the interferon system.[/h] Killip MJ[SUP]1[/SUP], Fodor E[SUP]2[/SUP], Randall RE[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] The host interferon (IFN) response represents one of the first barriers that influenza viruses must surmount in order to establish an infection. Many advances have been made in recent years in the understanding of the interactions between influenza viruses and the interferon system. In this review, we summarise recent work regarding activation of the type I IFN response by influenza viruses, including attempts to identify the viral RNA responsible for IFN induction, the stage of the virus life cycle at which it is generated and the role of defective viruses in this process.
Copyright ? 2015. Published by Elsevier B.V.
[h=4]KEYWORDS:[/h] Influenza viruses; RIG-I; innate immunity; interferon
PMID: 25678267 [PubMed - as supplied by publisher]