tetano
Editor, Senior Moderator
Cell Host Microbe. 2019 Jan 24. pii: S1931-3128(19)30039-3. doi: 10.1016/j.chom.2019.01.002. [Epub ahead of print]
[h=1]Influenza Virus Vaccination Elicits Poorly Adapted B Cell Responses in Elderly Individuals.[/h] Henry C[SUP]1[/SUP], Zheng NY[SUP]2[/SUP], Huang M[SUP]2[/SUP], Cabanov A[SUP]2[/SUP], Rojas KT[SUP]2[/SUP], Kaur K[SUP]2[/SUP], Andrews SF[SUP]2[/SUP], Palm AE[SUP]2[/SUP], Chen YQ[SUP]2[/SUP], Li Y[SUP]3[/SUP], Hoskova K[SUP]2[/SUP], Utset HA[SUP]2[/SUP], Vieira MC[SUP]4[/SUP], Wrammert J[SUP]5[/SUP], Ahmed R[SUP]6[/SUP], Holden-Wiltse J[SUP]7[/SUP], Topham DJ[SUP]8[/SUP], Treanor JJ[SUP]9[/SUP], Ertl HC[SUP]10[/SUP], Schmader KE[SUP]11[/SUP], Cobey S[SUP]4[/SUP], Krammer F[SUP]12[/SUP], Hensley SE[SUP]3[/SUP], Greenberg H[SUP]13[/SUP], He XS[SUP]13[/SUP], Wilson PC[SUP]14[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Influenza is a leading cause of death in the elderly, and the vaccine protects only a fraction of this population. A key aspect of antibody-mediated anti-influenza virus immunity is adaptation to antigenically distinct epitopes on emerging strains. We examined factors contributing to reduced influenza vaccine efficacy in the elderly and uncovered a dramatic reduction in the accumulation of de novo immunoglobulin gene somatic mutations upon vaccination. This reduction is associated with a significant decrease in the capacity of antibodies to target the viral glycoprotein, hemagglutinin (HA), and critical protective epitopes surrounding the HA receptor-binding domain. Immune escape by antigenic drift, in which viruses generate mutations in key antigenic epitopes, becomes highly exaggerated. Because of this reduced adaptability, most B cells activated in the elderly cohort target highly conserved but less potent epitopes. Given these findings, vaccines driving immunoglobulin gene somatic hypermutation should be a priority to protect elderly individuals.
Copyright ? 2019 Elsevier Inc. All rights reserved.
[h=4]KEYWORDS:[/h] elderly population; immunoglobulin genes; influenza vaccine; monoclonal antibodies
PMID: 30795982 DOI: 10.1016/j.chom.2019.01.002
[h=1]Influenza Virus Vaccination Elicits Poorly Adapted B Cell Responses in Elderly Individuals.[/h] Henry C[SUP]1[/SUP], Zheng NY[SUP]2[/SUP], Huang M[SUP]2[/SUP], Cabanov A[SUP]2[/SUP], Rojas KT[SUP]2[/SUP], Kaur K[SUP]2[/SUP], Andrews SF[SUP]2[/SUP], Palm AE[SUP]2[/SUP], Chen YQ[SUP]2[/SUP], Li Y[SUP]3[/SUP], Hoskova K[SUP]2[/SUP], Utset HA[SUP]2[/SUP], Vieira MC[SUP]4[/SUP], Wrammert J[SUP]5[/SUP], Ahmed R[SUP]6[/SUP], Holden-Wiltse J[SUP]7[/SUP], Topham DJ[SUP]8[/SUP], Treanor JJ[SUP]9[/SUP], Ertl HC[SUP]10[/SUP], Schmader KE[SUP]11[/SUP], Cobey S[SUP]4[/SUP], Krammer F[SUP]12[/SUP], Hensley SE[SUP]3[/SUP], Greenberg H[SUP]13[/SUP], He XS[SUP]13[/SUP], Wilson PC[SUP]14[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Influenza is a leading cause of death in the elderly, and the vaccine protects only a fraction of this population. A key aspect of antibody-mediated anti-influenza virus immunity is adaptation to antigenically distinct epitopes on emerging strains. We examined factors contributing to reduced influenza vaccine efficacy in the elderly and uncovered a dramatic reduction in the accumulation of de novo immunoglobulin gene somatic mutations upon vaccination. This reduction is associated with a significant decrease in the capacity of antibodies to target the viral glycoprotein, hemagglutinin (HA), and critical protective epitopes surrounding the HA receptor-binding domain. Immune escape by antigenic drift, in which viruses generate mutations in key antigenic epitopes, becomes highly exaggerated. Because of this reduced adaptability, most B cells activated in the elderly cohort target highly conserved but less potent epitopes. Given these findings, vaccines driving immunoglobulin gene somatic hypermutation should be a priority to protect elderly individuals.
Copyright ? 2019 Elsevier Inc. All rights reserved.
[h=4]KEYWORDS:[/h] elderly population; immunoglobulin genes; influenza vaccine; monoclonal antibodies
PMID: 30795982 DOI: 10.1016/j.chom.2019.01.002