tetano
Editor, Senior Moderator
Antiviral Res. 2013 Jun 5. pii: S0166-3542(13)00145-9. doi: 10.1016/j.antiviral.2013.05.014. [Epub ahead of print]
Inhibition of herpesvirus and influenza virus replication by blocking polymerase subunit interactions.
Pal? G, Loregian A.
Source
Department of Molecular Medicine, University of Padua, via Gabelli 63, 35121 Padua, Italy. Electronic address: giorgio.palu@unipd.it.
Abstract
Protein-protein interactions (PPIs) play a key role in many biological processes, including virus replication in the host cell. Since most of the PPIs are functionally essential, a possible strategy to inhibit virus replication is based on the disruption of viral protein complexes by peptides or small molecules that interfere with subunit interactions. In particular, an attractive target for antiviral drugs is the binding between the subunits of essential viral enzymes. This review describes the development of new antiviral compounds that inhibit herpesvirus and influenza virus replication by blocking interactions between subunit proteins of their polymerase complexes.
Copyright ? 2013. Published by Elsevier B.V.
PMID:
23748148
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23748148
Inhibition of herpesvirus and influenza virus replication by blocking polymerase subunit interactions.
Pal? G, Loregian A.
Source
Department of Molecular Medicine, University of Padua, via Gabelli 63, 35121 Padua, Italy. Electronic address: giorgio.palu@unipd.it.
Abstract
Protein-protein interactions (PPIs) play a key role in many biological processes, including virus replication in the host cell. Since most of the PPIs are functionally essential, a possible strategy to inhibit virus replication is based on the disruption of viral protein complexes by peptides or small molecules that interfere with subunit interactions. In particular, an attractive target for antiviral drugs is the binding between the subunits of essential viral enzymes. This review describes the development of new antiviral compounds that inhibit herpesvirus and influenza virus replication by blocking interactions between subunit proteins of their polymerase complexes.
Copyright ? 2013. Published by Elsevier B.V.
PMID:
23748148
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23748148