tetano
Editor, Senior Moderator
Biomed Pharmacother. 2017 Jan 9;87:583-588. doi: 10.1016/j.biopha.2016.12.117. [Epub ahead of print]
[h=1]Inhibition viral RNP and anti-inflammatory activity of coumarins against influenza virus.[/h] Wang Y[SUP]1[/SUP], Yan W[SUP]2[/SUP], Chen Q[SUP]1[/SUP], Huang W[SUP]1[/SUP], Yang Z[SUP]3[/SUP], Li X[SUP]4[/SUP], Wang X[SUP]5[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Influenza viruses pose a severe threat to human health and a significant increase in antiviral drug-resistant among influenza viruses worldwide has been observed. Therefore, there is an urgent need to develop the new antiviral drugs, specifically from the natural products. In this study, the anti-viral and anti-inflammatory activities of coumarins against influenza A virus in vitro were investigated. One of the derivatives eleutheroside B[SUB]1[/SUB] showed a wide spectrum of anti- human influenza virus effect with the IC[SUB]50[/SUB] value of 64-125μg/ml in vitro, but it showed no effects against avian influenza virus. The time of addition was done and the results indicated that it had a potent antiviral effect when added at 0-6h, and also the virus yield was reduced by 60%. The influenza virus ribonucleoprotein was inhibited at 200μg/ml, and also the NP mRNA expression was inhibited at 50 and 200μg/ml. The expression level of cytokines and chemokines influenced by eleutheroside B[SUB]1[/SUB] was further demonstrated, the IL-6, CXCL-8, CCL-2 expression were all inhibited by the eleuthe roside B[SUB]1[/SUB] at concentration 200μg/ml. The findings of study suggest that eleutheroside B[SUB]1[/SUB] can be as potential agent to develop for the prevention and treatment of influenza A virus.
Copyright ? 2016 Elsevier Masson SAS. All rights reserved.
[h=4]KEYWORDS:[/h] Anti-inflammatory; Coumarins; Eleutheroside B(1); Influenza virus; Viral ribonucleoprotein
PMID: 28081470 DOI: 10.1016/j.biopha.2016.12.117
[PubMed - as supplied by publisher]
[h=1]Inhibition viral RNP and anti-inflammatory activity of coumarins against influenza virus.[/h] Wang Y[SUP]1[/SUP], Yan W[SUP]2[/SUP], Chen Q[SUP]1[/SUP], Huang W[SUP]1[/SUP], Yang Z[SUP]3[/SUP], Li X[SUP]4[/SUP], Wang X[SUP]5[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Influenza viruses pose a severe threat to human health and a significant increase in antiviral drug-resistant among influenza viruses worldwide has been observed. Therefore, there is an urgent need to develop the new antiviral drugs, specifically from the natural products. In this study, the anti-viral and anti-inflammatory activities of coumarins against influenza A virus in vitro were investigated. One of the derivatives eleutheroside B[SUB]1[/SUB] showed a wide spectrum of anti- human influenza virus effect with the IC[SUB]50[/SUB] value of 64-125μg/ml in vitro, but it showed no effects against avian influenza virus. The time of addition was done and the results indicated that it had a potent antiviral effect when added at 0-6h, and also the virus yield was reduced by 60%. The influenza virus ribonucleoprotein was inhibited at 200μg/ml, and also the NP mRNA expression was inhibited at 50 and 200μg/ml. The expression level of cytokines and chemokines influenced by eleutheroside B[SUB]1[/SUB] was further demonstrated, the IL-6, CXCL-8, CCL-2 expression were all inhibited by the eleuthe roside B[SUB]1[/SUB] at concentration 200μg/ml. The findings of study suggest that eleutheroside B[SUB]1[/SUB] can be as potential agent to develop for the prevention and treatment of influenza A virus.
Copyright ? 2016 Elsevier Masson SAS. All rights reserved.
[h=4]KEYWORDS:[/h] Anti-inflammatory; Coumarins; Eleutheroside B(1); Influenza virus; Viral ribonucleoprotein
PMID: 28081470 DOI: 10.1016/j.biopha.2016.12.117
[PubMed - as supplied by publisher]