tetano
Editor, Senior Moderator
Int Immunopharmacol
. 2023 Oct 5;124(Pt B):110994.
doi: 10.1016/j.intimp.2023.110994. Online ahead of print. Monocytes subpopulations pattern in the acute respiratory syndrome coronavirus 2 virus infection and after long COVID-19
Vanessa Ingrid Cardoso Pereira[SUP] 1 [/SUP], Lacy Cardoso de Brito Junior[SUP] 2 [/SUP], Luiz Fabio Magno Falcão[SUP] 3 [/SUP], Pedro Fernando da Costa Vasconcelos[SUP] 4 [/SUP], Juarez Antônio Simões Quaresma[SUP] 5 [/SUP], Ana Virgínia Van Dem Berg[SUP] 6 [/SUP], Ana Paula Silveira Paixão[SUP] 7 [/SUP], Roberta Isabella Senna Ferreira[SUP] 8 [/SUP], Izabela Bezerra Costa Diks[SUP] 9 [/SUP]
Affiliations
Introdution and objective: The present study sought to characterize the pattern of monocyte subpopulations in patients during the course of the infections caused by SARS-CoV-2 virus or who presented long COVID-19 syndrome compared to monocytes from patients with zika virus (Zika) or chikungunya virus (CHIKV).
Casuistry: Study with 89 peripheral blood samples from patients, who underwent hemogram and serology (IgG and IgM) for detection of Zika (Control Group 1, n = 18) or CHIKV (Control Group 2, n = 9), and from patients who underwent hemogram and reverse transcription polymerase chain reaction for detection of SARS-CoV-2 at the acute phase of the disease (Group 3, n = 19); and of patients who presented long COVID-19 syndrome (Group 4, n = 43). The monocyte and subpopulations counts were performed by flow cytometry.
Results: No significant difference was observed in the total number of monocytes between the groups. The classical (CD14[SUP]++[/SUP]CD16[SUP]-[/SUP]) and intermediate (CD14[SUP]+[/SUP]CD16[SUP]+[/SUP]) monocytes counts were increased in patients with acute infection or with long COVID-19 syndrome. The monocytes subpopulations counts were lower in patients with infection Zika or CHIKV.
Conclusion: Increase in the monocyte subpopulations in patients with acute infection or with long COVID-19 syndrome may be an important finding of differentiated from the infection Zika or CHIKV.
Keywords: Chikungunya virus; Immunophenotyping; Monocytes activated killer; SARS-CoV-2; Zika virus.
. 2023 Oct 5;124(Pt B):110994.
doi: 10.1016/j.intimp.2023.110994. Online ahead of print. Monocytes subpopulations pattern in the acute respiratory syndrome coronavirus 2 virus infection and after long COVID-19
Vanessa Ingrid Cardoso Pereira[SUP] 1 [/SUP], Lacy Cardoso de Brito Junior[SUP] 2 [/SUP], Luiz Fabio Magno Falcão[SUP] 3 [/SUP], Pedro Fernando da Costa Vasconcelos[SUP] 4 [/SUP], Juarez Antônio Simões Quaresma[SUP] 5 [/SUP], Ana Virgínia Van Dem Berg[SUP] 6 [/SUP], Ana Paula Silveira Paixão[SUP] 7 [/SUP], Roberta Isabella Senna Ferreira[SUP] 8 [/SUP], Izabela Bezerra Costa Diks[SUP] 9 [/SUP]
Affiliations
- PMID: 37804653
- DOI: 10.1016/j.intimp.2023.110994
Introdution and objective: The present study sought to characterize the pattern of monocyte subpopulations in patients during the course of the infections caused by SARS-CoV-2 virus or who presented long COVID-19 syndrome compared to monocytes from patients with zika virus (Zika) or chikungunya virus (CHIKV).
Casuistry: Study with 89 peripheral blood samples from patients, who underwent hemogram and serology (IgG and IgM) for detection of Zika (Control Group 1, n = 18) or CHIKV (Control Group 2, n = 9), and from patients who underwent hemogram and reverse transcription polymerase chain reaction for detection of SARS-CoV-2 at the acute phase of the disease (Group 3, n = 19); and of patients who presented long COVID-19 syndrome (Group 4, n = 43). The monocyte and subpopulations counts were performed by flow cytometry.
Results: No significant difference was observed in the total number of monocytes between the groups. The classical (CD14[SUP]++[/SUP]CD16[SUP]-[/SUP]) and intermediate (CD14[SUP]+[/SUP]CD16[SUP]+[/SUP]) monocytes counts were increased in patients with acute infection or with long COVID-19 syndrome. The monocytes subpopulations counts were lower in patients with infection Zika or CHIKV.
Conclusion: Increase in the monocyte subpopulations in patients with acute infection or with long COVID-19 syndrome may be an important finding of differentiated from the infection Zika or CHIKV.
Keywords: Chikungunya virus; Immunophenotyping; Monocytes activated killer; SARS-CoV-2; Zika virus.