tetano
Editor, Senior Moderator
Int J Appl Basic Med Res
. Jan-Mar 2022;12(1):18-23.
doi: 10.4103/ijabmr.ijabmr_516_21. Epub 2022 Jan 31.
Immunoglobulin-G Antibodies against Severe Acute Respiratory Syndrome - Coronavirus-2 among Health-Care Workers: A Serosurveillance Study from India
Om Prakash[SUP] 1 [/SUP], Bhavin Solanki[SUP] 1 [/SUP], Jay Sheth[SUP] 2 [/SUP], Hemendra Acharya[SUP] 1 [/SUP], Swati Acharya[SUP] 1 [/SUP], Mital Vinzuda[SUP] 3 [/SUP], Hari Patani[SUP] 3 [/SUP]
Affiliations
Abstract
Background: Seropositivity among health-care workers (HCWs) may help in better understanding of the immune response after COVID-19 infection.
Objectives: To estimate seropositivity among HCWs and to compare available variables with seropositivity to understand the factors affecting seropositivity.
Materials and methods: A serosurveillance among HCWs was carried out using population proportion sampling during the second half of October 2020 in the city of Ahmedabad using the Covid-Kavach (immunoglobulin G [IgG] ELISA Antibody testing kit). Simple proportions and appropriate statistical tests were used as needed.
Results: As on October' 2020, HCWs in Ahmedabad demonstrated a seropositivity of 20.84% (95% confidence interval [CI] 19.00-22.81%). Seropositivity among HCWs was lower than that of the general population (24.20%) which was estimated as part of the same study. Female HCWs had higher seropositivity 22.14% (95% CI 19.74-24.74%) as compared to 18.82% (95% CI 16.06-21.93%) among male HCWs and the difference was statistically not significant (Z = 1.66, P = 0.097). Age groups with increasing age show increasing trend in the seropositivity among HCWs.
Conclusion: As on October 2020, with 20.84% seropositivity among HCWs in Ahmedabad, one in every five HCW already demonstrate IgG antibodies against severe acute respiratory syndrome- coronavirus-2. Further scientific studies on seropositivity and the factors affecting the seropositivity may be carried out to uncover more details of immune reaction after COVID-19 infection.
Keywords: COVID-19; Covid Kavach; health-care workers; immunity; immunoglobulin G antibodies; sero-surveillance; severe acute respiratory syndrome – coronavirus-2.
. Jan-Mar 2022;12(1):18-23.
doi: 10.4103/ijabmr.ijabmr_516_21. Epub 2022 Jan 31.
Immunoglobulin-G Antibodies against Severe Acute Respiratory Syndrome - Coronavirus-2 among Health-Care Workers: A Serosurveillance Study from India
Om Prakash[SUP] 1 [/SUP], Bhavin Solanki[SUP] 1 [/SUP], Jay Sheth[SUP] 2 [/SUP], Hemendra Acharya[SUP] 1 [/SUP], Swati Acharya[SUP] 1 [/SUP], Mital Vinzuda[SUP] 3 [/SUP], Hari Patani[SUP] 3 [/SUP]
Affiliations
- PMID: 35265476
- PMCID: PMC8848555
- DOI: 10.4103/ijabmr.ijabmr_516_21
Abstract
Background: Seropositivity among health-care workers (HCWs) may help in better understanding of the immune response after COVID-19 infection.
Objectives: To estimate seropositivity among HCWs and to compare available variables with seropositivity to understand the factors affecting seropositivity.
Materials and methods: A serosurveillance among HCWs was carried out using population proportion sampling during the second half of October 2020 in the city of Ahmedabad using the Covid-Kavach (immunoglobulin G [IgG] ELISA Antibody testing kit). Simple proportions and appropriate statistical tests were used as needed.
Results: As on October' 2020, HCWs in Ahmedabad demonstrated a seropositivity of 20.84% (95% confidence interval [CI] 19.00-22.81%). Seropositivity among HCWs was lower than that of the general population (24.20%) which was estimated as part of the same study. Female HCWs had higher seropositivity 22.14% (95% CI 19.74-24.74%) as compared to 18.82% (95% CI 16.06-21.93%) among male HCWs and the difference was statistically not significant (Z = 1.66, P = 0.097). Age groups with increasing age show increasing trend in the seropositivity among HCWs.
Conclusion: As on October 2020, with 20.84% seropositivity among HCWs in Ahmedabad, one in every five HCW already demonstrate IgG antibodies against severe acute respiratory syndrome- coronavirus-2. Further scientific studies on seropositivity and the factors affecting the seropositivity may be carried out to uncover more details of immune reaction after COVID-19 infection.
Keywords: COVID-19; Covid Kavach; health-care workers; immunity; immunoglobulin G antibodies; sero-surveillance; severe acute respiratory syndrome – coronavirus-2.